| Literature DB >> 1414247 |
H B Verbiest1, J S Straver, J P Colombo, J C van der Vijver, T C van Woerkom.
Abstract
Valproic acid induced coma is presented in an adult patient without a history of metabolic disease. Liver biopsy revealed a reduction in activity of carbamyl phosphate synthetase-I, an enzyme obligated for transformation of ammonia to urea in the urea cycle. After recovery CT scan follow-up showed marked cerebral atrophy which did not exist prior to the state of coma. Risk factors are discussed.Entities:
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Year: 1992 PMID： 1414247 DOI： 10.1111/j.1600-0404.1992.tb05085.x
Source DB: PubMed Journal: Acta Neurol Scand ISSN： 0001-6314 Impact factor: 3.209