Literature DB >> 14137941

CITRATE CLEAVAGE ENZYME IN LIVERS OF OBESE AND NONOBESE MICE.

M S KORNACKER, J M LOWENSTEIN.   

Abstract

The specific activity of the citrate cleavage enzyme is 3.3 times greater in livers of obese mice than in livers of their nonobese litter mates. The difference persists during starvation. The specific activity of the acetate activating enzyme is approximately the same in the livers of both types of animals. It is proposed that a high activity of citrate cleavage enzyme is one of the factors responsible for obesity.

Entities:  

Keywords:  ACETATES; ADENINE NUCLEOTIDES; ADENOSINE TRIPHOSPHATE; CARBOHYDRATE METABOLISM; CARBON ISOTOPES; CITRATES; COENZYME A; EXPERIMENTAL LAB STUDY; LIPID METABOLISM; LIVER ENZYMOLOGY; MICE; MITOCHONDRIA; OBESITY; STARVATION

Mesh：

Substances：

Year:  1964        PMID： 14137941     DOI： 10.1126/science.144.3621.1027

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Desaturation of stearic acid by liver and adipose tissue from obese-hyperglycaemic mice (ob/ob).

Authors:  M Enser
Journal:  Biochem J       Date:  1975-06       Impact factor: 3.857

2.  Abnormalities in lipogenesis and triglyceride secretion by perfused livers of obese-hyperglycaemic (ob-ob) mice: relationship with hyperinsulinaemia.

Authors:  F Assimacopoulos-Jeannet; A Singh; Y Le Marchand; E G Loten; B Jeanrenaud
Journal:  Diabetologia       Date:  1974-04       Impact factor: 10.122

3.  The metabolism of ketones, triglyceride and monoglyceride in livers of obese hyperglycaemic mice.

Authors:  J M Stein; P D Bewsher; J M Stowers
Journal:  Diabetologia       Date:  1970-12       Impact factor: 10.122

4.  Studies on lipogenesis in vivo: Fatty acid and cholesterol synthesis in hyperglycaemic-obese mice.

Authors:  G R Jansen; M E Zanetti; C F Hutchison
Journal:  Biochem J       Date:  1967-03       Impact factor: 3.857

5.  CITRATE AND THE CONVERSION OF CARBOHYDATE INTO FAT. ACTIVITIES OF CITRATE-CLEAVAGE ENZYME AND ACETATE THIOKINASE IN LIVERS OF NORMAL AND DIABETIC RATS.

Authors:  M S KORNACKER; J M LOWENSTEIN
Journal:  Biochem J       Date:  1965-06       Impact factor: 3.857

6.  Synthesis and degradation of liver acetyl coenzyme A carboxylase in genetically obese mice.

Authors:  S Nakanishi; S Numa
Journal:  Proc Natl Acad Sci U S A       Date:  1971-09       Impact factor: 11.205

7.  Citrate and the conversion of carbohydrate into fat. Citrate cleavage in obesity and lactation.

Authors:  A F Spencer; J M Lowenstein
Journal:  Biochem J       Date:  1966-06       Impact factor: 3.857
  7 in total

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