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Literature DB >> 1413526

Cell receptor-independent infection by a neurotropic murine coronavirus.

T M Gallagher¹, M J Buchmeier, S Perlman.

Abstract

The cellular receptors for a coronavirus, mouse hepatitis virus (MHV), have been recently identified as one or more members of the carcinoembryonic antigen (CEA) family. The neurotropic JHM strain of MHV (MHV-JHM) possesses a highly fusogenic surface (S) glycoprotein. This protein is now shown to promote the spread of MHV into cells lacking the specific CEA-related MHV receptor. Resistant cells are recruited into MHV-induced syncytium with consequent production of progeny virus. Cell-to-cell spread of virus via membrane fusion without the requirement for specific cell surface receptor offers a novel way for virus to spread within infected hosts.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1992 PMID： 1413526 PMCID： PMC7131763 DOI： 10.1016/0042-6822(92)90223-c

Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616

34 in total

1. Functional analysis of the coronavirus MHV-JHM surface glycoproteins in vaccinia virus recombinants.

Authors: M Pfleiderer; E Routledge; S G Siddell
Journal: Adv Exp Med Biol Date: 1990 Impact factor: 2.622

2. High level transient expression of the murine coronavirus haemagglutinin-esterase.

Authors: M Pfleiderer; E Routledge; G Herrler; S G Siddell
Journal: J Gen Virol Date: 1991-06 Impact factor: 3.891

3. Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins.

Authors: R K Williams; G S Jiang; K V Holmes
Journal: Proc Natl Acad Sci U S A Date: 1991-07-01 Impact factor: 11.205

4. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.

Authors: T R Fuerst; E G Niles; F W Studier; B Moss
Journal: Proc Natl Acad Sci U S A Date: 1986-11 Impact factor: 11.205

5. Alteration of the pH dependence of coronavirus-induced cell fusion: effect of mutations in the spike glycoprotein.

Authors: T M Gallagher; C Escarmis; M J Buchmeier
Journal: J Virol Date: 1991-04 Impact factor: 5.103

6. Histochemical staining of clonal mammalian cell lines expressing E. coli beta galactosidase indicates heterogeneous expression of the bacterial gene.

Authors: G R MacGregor; A E Mogg; J F Burke; C T Caskey
Journal: Somat Cell Mol Genet Date: 1987-05

7. Subacute sclerosing panencephalitis is typically characterized by alterations in the fusion protein cytoplasmic domain of the persisting measles virus.

Authors: A Schmid; P Spielhofer; R Cattaneo; K Baczko; V ter Meulen; M A Billeter
Journal: Virology Date: 1992-06 Impact factor: 3.616

8. In vivo and in vitro models of demyelinating disease: efficiency of virus spread and formation of infectious centers among glial cells is genetically determined by the murine host.

Authors: G A Wilson; S Dales
Journal: J Virol Date: 1988-09 Impact factor: 5.103

6. Intracellular complexes of viral spike and cellular receptor accumulate during cytopathic murine coronavirus infections.

Authors: P V Rao; T M Gallagher
Journal: J Virol Date: 1998-04 Impact factor: 5.103

7. Enhanced virulence mediated by the murine coronavirus, mouse hepatitis virus strain JHM, is associated with a glycine at residue 310 of the spike glycoprotein.

Authors: Evelena Ontiveros; Taeg S Kim; Thomas M Gallagher; Stanley Perlman
Journal: J Virol Date: 2003-10 Impact factor: 5.103

Cell receptor-independent infection by a neurotropic murine coronavirus.

1. Functional analysis of the coronavirus MHV-JHM surface glycoproteins in vaccinia virus recombinants.

2. High level transient expression of the murine coronavirus haemagglutinin-esterase.

3. Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins.

4. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.

5. Alteration of the pH dependence of coronavirus-induced cell fusion: effect of mutations in the spike glycoprotein.

6. Histochemical staining of clonal mammalian cell lines expressing E. coli beta galactosidase indicates heterogeneous expression of the bacterial gene.

7. Subacute sclerosing panencephalitis is typically characterized by alterations in the fusion protein cytoplasmic domain of the persisting measles virus.

8. In vivo and in vitro models of demyelinating disease: efficiency of virus spread and formation of infectious centers among glial cells is genetically determined by the murine host.

9. Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV.

10. Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats. A preliminary report.

1. Expression of the mouse hepatitis virus receptor by central nervous system microglia.

Review 2. The molecular biology of coronaviruses.

3. Neurovirulent Murine Coronavirus JHM.SD Uses Cellular Zinc Metalloproteases for Virus Entry and Cell-Cell Fusion.

4. Redirecting coronavirus to a nonnative receptor through a virus-encoded targeting adapter.

5. Episodic evolution mediates interspecies transfer of a murine coronavirus.

6. Intracellular complexes of viral spike and cellular receptor accumulate during cytopathic murine coronavirus infections.

7. Enhanced virulence mediated by the murine coronavirus, mouse hepatitis virus strain JHM, is associated with a glycine at residue 310 of the spike glycoprotein.

Review 8. Structure, Function, and Evolution of Coronavirus Spike Proteins.

Review 9. Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission.

10. A mechanism of virus-induced demyelination.