| Literature DB >> 14131396 |
Abstract
The mechanism whereby sulfonamyl diuretics are effective is through the blockage of the renal tubular reabsorption of chloride. The excretion of sodium, potassium and water is a passive one to maintain ionic equilibrium. Chlorothiazide has been shown to be almost ineffective as a diuretic agent per se. Although it does block a moiety of the renal tubular reabsorption of bicarbonate, the effect is merely a transient one.Entities:
Keywords: ACETAZOLAMIDE; ACIDOSIS; ALKALOSIS; AMMONIA; BENZOTHIADIAZINES; BLOOD CHEMICAL ANALYSIS; CHLOROTHIAZIDE; DIURETICS; HYDROCHLOROTHIAZIDE; KIDNEY TUBULES; METHYCLOTHIAZIDE; PHARMACOLOGY; TOXICOLOGIC REPORT
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Year: 1964 PMID： 14131396 PMCID： PMC1515389
Source DB: PubMed Journal: Calif Med ISSN： 0008-1264