| Literature DB >> 1412190 |
B Guerrero1, C L Arocha-Piñango.
Abstract
In this paper, we demonstrated that the procoagulant action of Lonomia achelous (Cramer) is due in part to a component that activates prothrombin. The activation by crude venom and Fractions obtained by gel filtration on Sephadex G-75 is not dependent of phospholipid, Ca++ or Factor V. The activation of prothrombin by Fraction I is greatly stimulated by Factor V in the presence of phospholipid and Ca++; in presence of SBTI, we found that the Fraction I and Factor Xa act in a similar manner. These results suggest that the Fraction I is a Factor Xa - like prothrombin activator.Entities:
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Year: 1992 PMID： 1412190 DOI： 10.1016/0049-3848(92)90187-f
Source DB: PubMed Journal: Thromb Res ISSN： 0049-3848 Impact factor: 3.944