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Literature DB >> 14110757

THE EFFECT OF CERTAIN ETHYLENEIMINES ON RENAL FUNCTION.

Abstract

Certain simple derivatives of ethyleneimine cause an intense and prolonged diuresis in nonhydrated rats. Sodium, potassium and chloride excretion is unaffected by these compounds. Ethyleneimine also causes a diuresis in the rat, but the polyfunctional compound thiotepa is ineffective. The relationship between structure and activity of a number of compounds is discussed with particular reference to the possibility that the diuresis is due to the in vivo liberation of ethyleneimine.

Entities: Chemical Species

Keywords: ANTINEOPLASTIC AGENTS; CHLORIDES; DIURESIS; EXPERIMENTAL LAB STUDY; IMINES; KIDNEY; PHARMACOLOGY; POTASSIUM; RATS; SODIUM; TOXICOLOGIC REPORT; URINE

Mesh：

Substances：

Year: 1963 PMID： 14110757 PMCID： PMC1703888 DOI： 10.1111/j.1476-5381.1963.tb02025.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

10 in total

3 in total

THE EFFECT OF CERTAIN ETHYLENEIMINES ON RENAL FUNCTION.

1. Comparative studies of the diuretics acetazolamide, aminometradine, chlorothiazide and theophylline.

2. Comparative effects of certain alkylating agents on the proliferation of normal and tumour tissue-haematopoiesis.

3. Relation of saluretic and hypotensive effects of hydrochlorothiazide in the rat.

4. Factors influencing diuresis in rats following total-body x-irradiation.

5. Excretion patterns of rats following totalbody exposure to x-radiation.

6. Pharmacology of spermine and spermidine; some effects on animals and bacteria.

7. Whole body x-irradiation, nitrogen excretion and the adrenal gland.

8. Experimental medullary necrosis of the kidney; a morphologic and functional study.

9. The effect of alkylating agents on male rat fertility.

10. METABOLIC STUDIES WITH DI(AZIRIDIN-1-YL) SULPHOXIDE (DIETHYLENEIMINOSULPHOXIDE).

1. Metabolic studies with certain ethyleneimine derivatives in relation to diuresis.

2. [Health damage and poisoning by action of ethylenimine].

3. METABOLIC STUDIES WITH DI(AZIRIDIN-1-YL) SULPHOXIDE (DIETHYLENEIMINOSULPHOXIDE).