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Literature DB >> 14110745

THE ACTION OF HISTAMINE ON THE ISOLATED HEART.

Abstract

A method is described for recording the coronary flow and the rate and the amplitude of contraction of an isolated heart maintained at constant temperature. Both histamine and noradrenaline increased the contractility of the guinea-pig heart. Pronethalol antagonized noradrenaline but not histamine. Mepyramine, 10-(2-pyrrolidin-1'-ylethyl)phenothiazine hydrochloride (pyrathiazine) and diphenhydramine reduced the contractility of the guinea-pig heart but did not antagonize the action of histamine. The influence of histamine and noradrenaline on coronary flow was variable but when the contractility of the heart increased there was a concomitant increase in coronary flow. Histamine decreased the contractility of the rat heart and the domestic fowl heart.

Entities: Chemical Species

Keywords: ANTIHISTAMINICS; BLOOD CIRCULATION; CORONARY VESSELS; DIPHENHYDRAMINE; EXPERIMENTAL LAB STUDY; GUINEA PIGS; HEART; HISTAMINE; NOREPINEPHRINE; PHARMACOLOGY; POULTRY; RATS; SYMPATHOLYTICS

Mesh：

Substances：

Year: 1963 PMID： 14110745 PMCID： PMC1703891 DOI： 10.1111/j.1476-5381.1963.tb02013.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

9 in total

1. Comparative activities of certain antihistamines on inhibition of isolated rabbit auricles.

Authors: H WANEBO; S KATSH; B BROMBERGER-BARNEA
Journal: Arch Int Pharmacodyn Ther Date: 1962-05-01

2. Pharmacology of a new adrenergic beta-receptor-blocking compound (Nethalide).

Authors: J W BLACK; J S STEPHENSON
Journal: Lancet Date: 1962-08-18 Impact factor: 79.321

3. The action of histamine and 5-hydroxytryptamine on isolated mammalian atria.

Authors: U TRENDELENBURG
Journal: J Pharmacol Exp Ther Date: 1960-12 Impact factor: 4.030

4. A method for the determination of pA2 at two minutes.

Authors: M F LOCKETT; A L BARTLET
Journal: J Pharm Pharmacol Date: 1956-01 Impact factor: 3.765

5. [Analysis of sympathomimetic effect of histamine on isolated mammal heart].

Authors: I WENT; E VARGA; E SZUCS; O FEHER
Journal: Acta Physiol Acad Sci Hung Date: 1954

6. The action of insulin in the isolated rat heart.

Authors: N M BLEEHEN; R B FISHER
Journal: J Physiol Date: 1954-02-26 Impact factor: 5.182

7. The physiological action of beta-iminazolylethylamine.

Authors: H H Dale; P P Laidlaw
Journal: J Physiol Date: 1910-12-31 Impact factor: 5.182

8. The action of ephedrine.

Authors: J H Gaddum; H Kwiatkowski
Journal: J Physiol Date: 1938-10-14 Impact factor: 5.182

9. [A sympathomimetic effect of histamine].

Authors: S WENT; E VARGA; E SZUCS; O FEHER
Journal: Naunyn Schmiedebergs Arch Exp Pathol Pharmakol Date: 1952

9 in total

18 in total

7. The role of H1 and H2-receptors in the coronary vascular response to histamine of isolated perfused hearts of guinea-pigs and rabbits.

Authors: K J Broadley
Journal: Br J Pharmacol Date: 1975-08 Impact factor: 8.739

8. Inotropic and electrophysiological effects of histamine on human ventricular heart muscle.

Authors: L Eckel; R W Gristwood; H Nawrath; D A Owen; P Satter
Journal: J Physiol Date: 1982-09 Impact factor: 5.182

9. H1 - and H2-receptor mediated responses to histamine on contractility and cyclic AMP of atrial and papillary muscles from guinea-pig hearts.

Authors: D Reinhardt; U Schmidt; O E Brodde; H J Schümann
Journal: Agents Actions Date: 1977-03

10. Anaphylaxis in the guinea-pig isolated heart: selective inhibition by burimamide of the positive inotropic and chronotropic effects of released histamine.

Authors: N Capurro; R Levi
Journal: Br J Pharmacol Date: 1973-08 Impact factor: 8.739