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Literature DB >> 14110741

AN ANTIHISTAMINE-LIKE SUBSTANCE (OR SUBSTANCES) IN EXTRACTS PREPARED FROM HUMAN TISSUES.

Abstract

A method for the extraction of an antihistamine-like substance (or substances) from human tissues is described. The method has demonstrated the presence of this active principle(s) in a large variety of human tissues, so far without exception. The substance(s) has a wide range of activity in antagonizing the in vitro effects of histamine, 5-hydroxytryptamine and bradykinin and the Schultz-Dale reaction on the guinea-pig ileum and rat uterus preparations.

Entities: Chemical Species

Keywords: ANAPHYLAXIS; ANTIHISTAMINICS; BRADYKININ; EXPERIMENTAL LAB STUDY; GUINEA PIGS; HISTAMINE; ILEUM; PHARMACOLOGY; RATS; SEROTONIN; TISSUE EXTRACTS; UTERUS

Mesh：

Substances：

Year: 1963 PMID： 14110741 PMCID： PMC1703880 DOI： 10.1111/j.1476-5381.1963.tb02009.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

7 in total

4. The presence in normal human urine of a substance or substances antagonizing histamine, 5-hydroxytryptamine, and acetylcholine (preliminary report).

Authors: B A KOVACS; K I MELVILLE
Journal: Can J Biochem Physiol Date: 1962-01

1 in total

1. Inhibition of ulcer formation by urine extracts with antihistamine activity.

Authors: B A Kovacs; K Voith
Journal: Br J Pharmacol Chemother Date: 1966-05

1 in total

AN ANTIHISTAMINE-LIKE SUBSTANCE (OR SUBSTANCES) IN EXTRACTS PREPARED FROM HUMAN TISSUES.

1. Studies with eosinophil leucocytes isolated from the blood of the horse.

2. Antihistamine activity in extracts of horse eosinophils.

3. Antihistamine activity of extracts prepared from buffy-coat layer of horse blood and from oak gall.

4. The presence in normal human urine of a substance or substances antagonizing histamine, 5-hydroxytryptamine, and acetylcholine (preliminary report).

5. The properties of the isolated granules from blood eosinophiles.

6. Antihistaminic effect of eosinophil leukocytes.

7. [Demonstration of a hitherto unknown antihistaminic agent formed in the body (resistin)].

1. Inhibition of ulcer formation by urine extracts with antihistamine activity.