Literature DB >> 14107477

ESTROGEN ADMINISTERED NEONATALLY AFFECTS ADULT SEXUAL BEHAVIOR IN MALE AND FEMALE RATS.

S LEVINE, R MULLINS.   

Abstract

The injection of 100 microg of estradiol benzoate into female rats 96 hours after birth abolished sexual receptivity in adulthood, even with estrogen and progesterone replacement after ovariectomy. The administration of testosterone propionate to these animals in adulthood elicited the full pattern of male sexual behavior. The same dose of estrogen given to male rats 96 hours after birth produced adults which were unable to achieve intromission, although they mounted as frequently as normal animals. Testosterone replacement after castration in adulthood reproduced this abnormal behavior.

Entities:  

Keywords:  ANIMALS, NEWBORN; CASTRATION; ESTRADIOL; EXPERIMENTAL LAB STUDY; PHARMACOLOGY; RATS; SEX BEHAVIOR; TESTOSTERONE

Mesh：

Substances：

Year:  1964        PMID： 14107477     DOI： 10.1126/science.144.3615.185

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

1.  Fetal hormones and the brain: Effect on sexual dimorphism of behavior-A review.

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Journal:  Arch Sex Behav       Date:  1971-09

Review 2.  Caveolin proteins and estrogen signaling in the brain.

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3.  Rebuttal of "Flawed Experimental Design Reveals the Need for Guidelines Requiring Appropriate Positive Controls in Endocrine Disruption Research" by (Vom Saal 2010).

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Review 4.  Estrogens in Male Physiology.

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Review 5.  Neural mechanisms of persistent aggression.

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6.  Estrogen treatment during development alters adult partner preference and reproductive behavior in female laboratory rats.

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Review 7.  A role for the androgen receptor in the sexual differentiation of the olfactory system in mice.

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8.  Sex differences and effects of neonatal aromatase inhibition on masculine and feminine copulatory potentials in prairie voles.

Authors:  Katharine V Northcutt; Joseph S Lonstein
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9.  Neonatal agonism of ERβ impairs male reproductive behavior and attractiveness.

Authors:  Alana W Sullivan; Peter Hamilton; Heather B Patisaul
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Review 10.  19-hydroxy Steroids in the Aromatase Reaction: Review on Expression and Potential Functions.

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  10 in total

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