Literature DB >> 14107431

GAMMA HYDROXYBUTYRATE AND GAMMA BUTYROLACTONE: CONCENTRATION IN RAT TISSUES DURING ANESTHESIA.

S P BESSMAN, S J SKOLNIK.   

Abstract

Gamma-hydroxybutyric acid, when administered to animals or human beings, causes sleep. It is convertible to gamma-butyrolactone, which also produces sleep. Tissue concentrations in rats after administration of these two compounds show that the induced sleep is related to the concentration of the lactone in the brain.

Entities:  

Keywords:  ANESTHETICS; BLOOD CHEMICAL ANALYSIS; BRAIN; BUTYRATES; EXPERIMENTAL LAB STUDY; HEART; HYDROXYBUTYRATES; LACTONES; LIVER; METABOLISM; MUSCLES; RATS

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Substances：

Year:  1964        PMID： 14107431     DOI： 10.1126/science.143.3610.1045

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  4 in total

1.  Pharmacokinetics of gamma-hydroxybutyric acid in alcohol dependent patients after single and repeated oral doses.

Authors:  S D Ferrara; S Zotti; L Tedeschi; G Frison; F Castagna; L Gallimberti; G L Gessa; P Palatini
Journal:  Br J Clin Pharmacol       Date:  1992-09       Impact factor: 4.335

2.  Factors in cerebrospinal fluid from goats that affect sleep and activity in rats.

Authors:  V Fencl; G Koski; J R Pappenheimer
Journal:  J Physiol       Date:  1971-08       Impact factor: 5.182

Review 3.  Behavioral analyses of GHB: receptor mechanisms.

Authors:  Lawrence P Carter; Wouter Koek; Charles P France
Journal:  Pharmacol Ther       Date:  2008-10-29       Impact factor: 12.310

4.  Repurposing of substances with lactone moiety for the treatment of γ-Hydroxybutyric acid and γ-Butyrolactone intoxication through modulating paraoxonase and PPARγ.

Authors:  Sepand Tehrani Fateh; Amir Salehi-Najafabadi
Journal:  Front Pharmacol       Date:  2022-07-22       Impact factor: 5.988
  4 in total

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