Literature DB >> 14104151

MICROAEROSOL ADMINISTRATION OF SYNTHETIC BETA-GAMMA-DIPALMITOYL-L-ALPHA-LECITHIN IN THE RESPIRATORY DISTRESS SYNDOME: A PRELIMINARY REPORT.

E ROBILLARD, Y ALARIE, P DAGENAIS-PERUSSE, E BARIL, A GUILBEAULT.   

Abstract

Synthetic L-alpha-lecithin was administered by inhalation to 11 infants suffering from respiratory distress. The L-alpha-lecithin was delivered by microaerosolization, at a concentration of 0.25% in a mixture of equal volumes of propylene glycol and water. This was done with the aim of decreasing the alveolar surface tension. In eight of the treated infants who survived, the respiratory distress was alleviated. The results are inconclusive but they justify further investigation.

Entities:  

Keywords:  AEROSOLS; ASPHYXIA NEONATORUM; HYALINE MEMBRANE DISEASE; LECITHINS

Mesh：

Substances：

Year:  1964        PMID： 14104151      PMCID： PMC1922135     

Source DB:  PubMed          Journal:  Can Med Assoc J        ISSN： 0008-4409            Impact factor:   8.262


  11 in total

1.  Correlation of mechancial properties of infant lungs with surface activity of extracts.

Authors:  P GRUENWALD; R P JOHNSON; R F HUSTEAD; J A CLEMENTS
Journal:  Proc Soc Exp Biol Med       Date:  1962-02

2.  Mechanical properties of lungs.

Authors:  J MEAD
Journal:  Physiol Rev       Date:  1961-04       Impact factor: 37.312

3.  Pulmonary surface tension.

Authors:  E S BROWN; R P JOHNSON; J A CLEMENTS
Journal:  J Appl Physiol       Date:  1959-09       Impact factor: 3.531

4.  Composition of surface-active material isolated from beef lung.

Authors:  M H KLAUS; J A CLEMENTS; R J HAVEL
Journal:  Proc Natl Acad Sci U S A       Date:  1961-11-15       Impact factor: 11.205

5.  Properties, function and origin of the alveolar lining layer.

Authors:  R E PATTLE
Journal:  Nature       Date:  1955-06-25       Impact factor: 49.962

6.  Surface tension of lung extracts.

Authors:  J A CLEMENTS
Journal:  Proc Soc Exp Biol Med       Date:  1957-05

7.  Lung deposition of fine dust particles.

Authors:  L DAUTREBANDE; H BECKMANN; W WALKENHORST
Journal:  AMA Arch Ind Health       Date:  1957-09

8.  Pulmonary surface tension and the mucus lining of the lungs: some theoretical considerations.

Authors:  J A CLEMENTS; E S BROWN; R P JOHNSON
Journal:  J Appl Physiol       Date:  1958-03       Impact factor: 3.531

9.  Inability to form a lung-lining film as a cause of the respiratory-distress syndrome in the newborn.

Authors:  R E PATTLE; A E CLAIREAUX; P A DAVIES; A H CAMERON
Journal:  Lancet       Date:  1962-09-08       Impact factor: 79.321

10.  On the retention of airborne particulates in the human lung: II.

Authors:  H D LANDAHL; T N TRACEWELL; W H LASSEN
Journal:  AMA Arch Ind Hyg Occup Med       Date:  1951-04
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  37 in total

1.  Resonance frequency in respiratory distress syndrome.

Authors:  S Lee; A D Milner
Journal:  Arch Dis Child Fetal Neonatal Ed       Date:  2000-11       Impact factor: 5.747

2.  Nebulization of Poractant alfa via a vibrating membrane nebulizer in spontaneously breathing preterm lambs with binasal continuous positive pressure ventilation.

Authors:  Matthias C Hütten; Elke Kuypers; Daan R Ophelders; Maria Nikiforou; Reint K Jellema; Hendrik J Niemarkt; Carola Fuchs; Markus Tservistas; Roberta Razetti; Federico Bianco; Boris W Kramer
Journal:  Pediatr Res       Date:  2015-08-31       Impact factor: 3.756

Review 3.  Exogenous surfactant treatments for neonatal respiratory distress syndrome and their potential role in the adult respiratory distress syndrome.

Authors:  T A Merritt; M Hallman; R Spragg; G P Heldt; N Gilliard
Journal:  Drugs       Date:  1989-10       Impact factor: 9.546

4.  Pulmonary surfactant: a surface chemistry viewpoint.

Authors:  R H Notter; P E Morrow
Journal:  Ann Biomed Eng       Date:  1975-06       Impact factor: 3.934

Review 5.  Aerosol delivery to ventilated newborn infants: historical challenges and new directions.

Authors:  Jan Mazela; Richard A Polin
Journal:  Eur J Pediatr       Date:  2010-09-28       Impact factor: 3.183

6.  [Not Available].

Authors: 
Journal:  Paediatr Child Health       Date:  2005-02       Impact factor: 2.253

7.  Recommendations for neonatal surfactant therapy.

Authors: 
Journal:  Paediatr Child Health       Date:  2005-02       Impact factor: 2.253

Review 8.  Colfosceril palmitate. A review of the therapeutic efficacy and clinical tolerability of a synthetic surfactant preparation (Exosurf Neonatal) in neonatal respiratory distress syndrome.

Authors:  K L Dechant; D Faulds
Journal:  Drugs       Date:  1991-11       Impact factor: 9.546

9.  Surfactant replacement therapy for neonatal respiratory distress syndrome.

Authors:  R Dhanireddy
Journal:  Indian J Pediatr       Date:  1990 Nov-Dec       Impact factor: 1.967

Review 10.  Surfactant replacement therapy.

Authors:  M J Kresch; W H Lin; R S Thrall
Journal:  Thorax       Date:  1996-11       Impact factor: 9.139
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