Literature DB >> 14100003

THE DIAGNOSTIC VALUE OF SERUM LEUCINE AMINOPEPTIDASE.

G MERICAS, E ANAGNOSTOU, S HADZIYANNIS, S KAKARI.   

Abstract

Serum leucine aminopeptidase determination was found to be a useful screening procedure for hepatobiliary disease in jaundiced and unjaundiced patients. Values under 1,000 units are of no help in the differential diagnosis of jaundice but values above 1,000 units are highly indicative of biliary obstruction. The differentiation of intra- from extrahepatic obstruction as well as of malignant from benign jaundice cannot generally be established by this single test.

Entities:  

Keywords:  ADOLESCENCE; AMINOPEPTIDASES; CHILD; CHOLECYSTITIS; CHOLELITHIASIS; COMMON BILE DUCT CALCULI; ENZYME TESTS; GERIATRICS; HEPATITIS, INFECTIOUS; HEPATITIS, TOXIC; JAUNDICE; LEUCINE; LIVER NEOPLASMS; NEOPLASM METASTASIS; PANCREATIC NEOPLASMS

Mesh：

Substances：

Year:  1964        PMID： 14100003      PMCID： PMC480671          DOI： 10.1136/jcp.17.1.52

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  14 in total

1.  Clinical value of serum leucine aminopeptidase determinations.

Authors:  B M BANKS; E P PINEDA; J A GOLDBARG; A M RUTENBURG
Journal:  N Engl J Med       Date:  1960-12-22       Impact factor: 91.245

2.  Leucine aminopeptidase: an aid to diagnosis.

Authors:  S WINSTEN; R H SELLER
Journal:  J Albert Einstein Med Cent (Phila)       Date:  1961-01

3.  [The behavior of leucine aminopeptidase and other enzymes in the blood serum in liver, biliary and pancreatic diseases].

Authors:  K H GOEGGEL; W CREUTZFELDT; J MURUCAS
Journal:  Dtsch Med Wochenschr       Date:  1960-09-30       Impact factor: 0.628

4.  Serum leucine aminopeptidase in carcinoma of pancreas and other diseases.

Authors:  A L MILLER; L WORSLEY
Journal:  Br Med J       Date:  1960-11-12

5.  Leucine aminopeptidase: significance of serum elevations in diseases of the hepatobilary-pancreatic system.

Authors:  H SHAY; D C SUN; H SIPLET
Journal:  Am J Dig Dis       Date:  1960-03

6.  Serum enzymes in the diagnosis of pancreatic and hepatic disease in anicteric patients.

Authors:  E P PINEDA; J A GOLDBARG; A M RUTENBURG
Journal:  Surg Forum       Date:  1960

7.  The diagnostic value of determinations of serum leucine aminopeptidase concentrations in carcinoma of the pancreas.

Authors:  J B HAMMOND; B D ROSENAK; E C KHOO
Journal:  Am J Dig Dis       Date:  1960-03

8.  [Leucine-aminopeptidase activity in blood serum & blister content. I. Studies on persons with a normal skin].

Authors:  O BRAUN-FALCO; K SALFELD
Journal:  Arch Klin Exp Dermatol       Date:  1957

9.  The colorimetric determination of leucine aminopeptidase in urine and serum of normal subjects and patients with cancer and other diseases.

Authors:  J A GOLDBARG; A M RUTENBURG
Journal:  Cancer       Date:  1958 Mar-Apr       Impact factor: 6.860

10.  The colorimetric determination of leucine aminopeptidase activity with L-leucyl-beta-naphthylamide hydrochloride.

Authors:  M N GREEN; K C TSOU; R BRESSLER; A M SELIGMAN
Journal:  Arch Biochem Biophys       Date:  1955-08       Impact factor: 4.013
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  4 in total

1.  [Leucine aminopeptidase (arylamidase) activity in the serum. Determination using leucine-p-nitroanilide as substrate].

Authors:  F Willig; I Greiner; H Stork; F H Schmidt
Journal:  Klin Wochenschr       Date:  1967-05-01

Review 2.  Enzyme assays in malignant disease.

Authors:  C B Cameron
Journal:  J Clin Pathol Suppl (Assoc Clin Pathol)       Date:  1970

3.  Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents.

Authors:  Laxman Devkota; Chen-Ming Lin; Tracy E Strecker; Yifan Wang; Justin K Tidmore; Zhi Chen; Rajsekhar Guddneppanavar; Christopher J Jelinek; Ramona Lopez; Li Liu; Ernest Hamel; Ralph P Mason; David J Chaplin; Mary Lynn Trawick; Kevin G Pinney
Journal:  Bioorg Med Chem       Date:  2016-01-06       Impact factor: 3.641

Review 4.  Activated molecular probes for enzyme recognition and detection.

Authors:  Meng Yuan; Ying Wu; Caiyan Zhao; Zhongxiang Chen; Lichao Su; Huanghao Yang; Jibin Song
Journal:  Theranostics       Date:  2022-01-01       Impact factor: 11.556
  4 in total

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