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Literature DB >> 14088824

RECENT ADVANCES IN THE PHYSIOLOGY OF GASTRIC ACID SECRETION.

Abstract

The classic scheme of gastric acid secretion which divided the digestive period into cephalic, gastric and antral phases has become obsolete in the last 10 years. These "phases" are now seen as concurrently acting mechanisms which depend upon one another to be fully efficient. About half of all gastrin released during a meal is dependent upon vagal stimulation of the antrum. Also, vagotomy desensitizes the acid-secreting parietal cells to the effect of all other types of stimuli.The number of parietal cells (parietal cell mass) varies greatly according to the gastric secretory activity of each individual. It is highest with duodenal ulcer and lowest with gastric ulcer.Parietal cell hyperplasia or atrophy can be induced experimentally, but the factors controlling the size of the parietal cell mass in man have not been studied.A scheme of acid secretion which incorporates recent advances is presented.

Entities: Disease Gene Species

Keywords: GASTRIC JUICE; GASTRIN; HISTAMINE; PATHOLOGY; PHYSIOLOGY; REVIEW; STOMACH; VAGUS NERVE

Mesh：

Substances：
Gastrins
Histamine

Year: 1963 PMID： 14088824 PMCID： PMC1922094

Source DB: PubMed Journal: Can Med Assoc J ISSN： 0008-4409 Impact factor: 8.262

32 in total

1. The role of the pancreas in gastric secretion.

Authors: B N CATCHPOLE
Journal: Gut Date: 1962-12 Impact factor: 23.059

2. Origin of the ulcerogenic hormone in endocrine induced ulcer.

Authors: R M ZOLLINGER; D W ELLIOTT; G L ENDAHL; G N GRANT; J T GOSWITZ; D A TAFT
Journal: Ann Surg Date: 1962-10 Impact factor: 12.969

3. Hypothalamic influence on gastric, mesenteric blood flow.

Authors: A S LEONARD; D M LONG; F THOMAS; A I WALDER; E T PETER; O H WANGENSTEEN
Journal: Surg Forum Date: 1962

4. Absence of demonstrable gastric secretagogue in normal pancreatic tissue.

Authors: G A HALLENBECK; C F CODE; C McILRATH
Journal: Gastroenterology Date: 1963-05 Impact factor: 22.682

5. The preparation and properties of gastrin.

Authors: R A GREGORY; H J TRACY
Journal: J Physiol Date: 1961-05 Impact factor: 5.182

6. Cell proliferation and migration as revealed by radioautography after injection of thymidine-H3 into male rats and mice.

Authors: B MESSIER; C P LEBLOND
Journal: Am J Anat Date: 1960-05

RECENT ADVANCES IN THE PHYSIOLOGY OF GASTRIC ACID SECRETION.

1. The role of the pancreas in gastric secretion.

2. Origin of the ulcerogenic hormone in endocrine induced ulcer.

3. Hypothalamic influence on gastric, mesenteric blood flow.

4. Absence of demonstrable gastric secretagogue in normal pancreatic tissue.

5. The preparation and properties of gastrin.

6. Cell proliferation and migration as revealed by radioautography after injection of thymidine-H3 into male rats and mice.

7. The effect of distension of the duodenum on gastric secretion.

8. Duodenal acidity and experimental peptic ulceration.

9. Inhibitory effect of pancreatic secretin on gastric secretion.

10. Confirmation of presence of a gastric secretory depressant in gastric juice of humans.

Review 1. Control of bacterial colonization in the glands and crypts.