Literature DB >> 14088076

INHIBITION OF SYNTHESIS OF THE CELL WALL OF STAPHYLOCOCCUS AUREUS BY CEPHALOTHIN.

T W CHANG, L WEINSTEIN.   

Abstract

Cephalothin, 7-(thiophene-2-acetamido)-cephalosporanic acid, suppresses synthesis of the cell of Staphylococcus aureus. Exposure to this agent led to a reduction in the degree of incorporation of carbon-14-lysine into the mucopeptide of the cell wall material and to an accumulation of N-acetyl glucosamine in the cell. The intensity of the lesions was comparable to that produced by penicillin.

Entities:  

Keywords:  ANTIBIOTICS; CEPHALOTHIN; CYTOLOGY; EXPERIMENTAL LAB STUDY; METABOLISM; STAPHYLOCOCCUS

Mesh:

Substances:

Year:  1964        PMID: 14088076     DOI: 10.1126/science.143.3608.807

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  4 in total

1.  Some effects of subinhibitory concentrations of antibiotics on bacteria.

Authors:  V Lorian
Journal:  Bull N Y Acad Med       Date:  1975-10

2.  SCE-129, antipseudomonal cephalosporin: in vitro and in vivo antibacterial activities.

Authors:  K Tsuchiya; M Kondo; H Nagatomo
Journal:  Antimicrob Agents Chemother       Date:  1978-02       Impact factor: 5.191

3.  MORPHOLOGICAL CHANGES IN GRAM-NEGATIVE BACILLI EXPOSED TO CEPHALOTHIN.

Authors:  T W CHANG; L WEINSTEIN
Journal:  J Bacteriol       Date:  1964-12       Impact factor: 3.490

Review 4.  The cephalosporins: activity and clinical use.

Authors:  A J Weinstein
Journal:  Drugs       Date:  1980-08       Impact factor: 9.546

  4 in total

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