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Literature DB >> 1408744

Interaction of the erythroid transcription factor cGATA-1 with a critical auto-regulatory element.

G Schwartzbauer¹, K Schlesinger, T Evans.

Abstract

We have performed a mutational analysis of the promoter for the chicken erythroid-specific GATA-1 transcription factor, and have investigated in detail the interaction of the factor with an upstream auto-regulatory element (ARE). We find that a single proximal GATA binding site of the ARE is required for promoter activity in primary erythroid cells; however, this minimal promoter is inappropriately active in fibroblasts. At least two molecules of GATA-1 can interact with the ARE, and sequences outside of the consensus site appear critical for the transcriptional activity of the bound protein. Finally, we provide evidence for complex protein/DNA interactions at the ARE, including the ability of GATA-1 to bend DNA.

Entities: Chemical Gene Species

Mesh：

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Year: 1992 PMID： 1408744 PMCID： PMC334168 DOI： 10.1093/nar/20.17.4429

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

30 in total

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Journal: Mol Cell Biol Date: 1991-12 Impact factor: 4.272

9. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1.

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10. The regulatory gene areA mediating nitrogen metabolite repression in Aspergillus nidulans. Mutations affecting specificity of gene activation alter a loop residue of a putative zinc finger.

Authors: B Kudla; M X Caddick; T Langdon; N M Martinez-Rossi; C F Bennett; S Sibley; R W Davies; H N Arst
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14 in total

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6. The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line.

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