Literature DB >> 14081669

OBSERVATIONS ON THE USE OF THE HEN AND RABBIT ISOLATED AURICLES FOR THE DETERMINATION OF INOTROPIC POTENCY.

J A LOCK.   

Abstract

The electrically driven, isolated auricles from the rabbit and the hen have been used to compare the inotropic potency of a bufodiene aglycone with ouabain. The results from the hen auricle permit conventional statistical treatment and show a good degree of reproducibility. Results of inotropic potencies and toxicity determinations on the two drugs are discussed.

Entities:  

Keywords:  ATROPINE; CALCIUM; CARDIAC GLYCOSIDES; ELECTRIC STIMULATION; EXPERIMENTAL LAB STUDY; GUINEA PIGS; HEART; OUABAIN; PHARMACOLOGY; POULTRY; RABBITS; RATS; STROPHANTHIN

Mesh：

Substances：

Year:  1963        PMID： 14081669      PMCID： PMC1703830          DOI： 10.1111/j.1476-5381.1963.tb01537.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  4 in total

1.  An automatic syringe for use with isolated organ baths.

Authors:  J A LOCK
Journal:  J Pharm Pharmacol       Date:  1961-06       Impact factor: 3.765

2.  Improved automatic apparatus for pharmacological assays on isolated preparations.

Authors:  A BOURA; J L MONGAR; H O SCHILD
Journal:  Br J Pharmacol Chemother       Date:  1954-03

3.  Cardiotonic substances from Bersama abyssinica fres. sub. species abyssinica.

Authors:  J A LOCK
Journal:  J Pharm Pharmacol       Date:  1962-08       Impact factor: 3.765

4.  Positive inotropic action of ouabain on rat ventricle strips.

Authors:  D T MASUOKA; P R SAUNDERS
Journal:  Proc Soc Exp Biol Med       Date:  1950-08
  4 in total
  1 in total

1.  The effect of temperature and frequency on the contractile force and inotropic response to ouabain, calcium and some other drugs of the hen isolated driven auricle.

Authors:  J A Lock
Journal:  Br J Pharmacol Chemother       Date:  1965-10
  1 in total

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