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Literature DB >> 14081666

POTENTIATION OF SOME CATECHOL AMINES BY PHENOXYBENZAMINE, GUANETHIDINE AND COCAINE.

Abstract

In rabbit isolated atria, cocaine, guanethidine and phenoxybenzamine increased the changes in rate and force of contractions caused by noradrenaline and adrenaline, but did not potentiate isoprenaline. The most likely explanation for this result is that the drugs interfere with one of the mechanisms in the heart by which noradrenaline and adrenaline, but not isoprenaline, are inactivated; a probable mechanism would be the uptake of noradrenaline into storage sites in the tissue. Cocaine, guanethidine and phenoxybenzamine did not potentiate noradrenaline and adrenaline acting on the rabbit isolated duodenum and the rat uterus.

Entities: Chemical Disease Species

Keywords: ACETYLCHOLINE; COCAINE; DOPAMINE; DUODENUM; EPINEPHRINE; EXPERIMENTAL LAB STUDY; GUANETHIDINE; HEART; ISOPROTERENOL; NOREPINEPHRINE; PHARMACOLOGY; PHENOXYBENZAMINE; RABBITS; RATS; UTERUS

Mesh：

Substances：

Year: 1963 PMID： 14081666 PMCID： PMC1703843 DOI： 10.1111/j.1476-5381.1963.tb01534.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

8 in total

1. A comparison of some of the cardiovascular actions of methylphenidate and cocaine.

Authors: R A MAXWELL; A J PLUMMER; H POVALSKI; F SCHNEIDER; H COOMBS
Journal: J Pharmacol Exp Ther Date: 1959-07 Impact factor: 4.030

2. Effect of drugs on the uptake and release of 3H-norepinephrine in the rat heart.

Authors: J AXELROD; G HERTTING; L POTTER
Journal: Nature Date: 1962-04-21 Impact factor: 49.962

3. The action of sympathomimetic amines on heart rate in relation to the effect of reserpine.

Authors: D BEJRABLAYA; J H BURN; J M WALKER
Journal: Br J Pharmacol Chemother Date: 1958-12

4. Enhancement of inhibitory and excitatory effects of catecholamines.

Authors: A P ROSZKOWSKI; G B KOELLE
Journal: J Pharmacol Exp Ther Date: 1960-03 Impact factor: 4.030

5. The estimation of adrenaline and allied substances in blood.

Authors: J H Gaddum; W S Peart; M Vogt
Journal: J Physiol Date: 1949-06-15 Impact factor: 5.182

6. Concerning the mechanisms of the cardiovascular actions of hexahydro-1-azepinepropionamidoxime (SU-4029).

Authors: R A MAXWELL; A J PLUMMER; A I DANIEL; F SCHNEIDER; H POVALSKI
Journal: J Pharmacol Exp Ther Date: 1958-10 Impact factor: 4.030

7. Mechanism of the positive inotropic responses to bretylium and guanethidine.

Authors: B BHAGAT; F E SHIDEMAN
Journal: Br J Pharmacol Chemother Date: 1963-02

8. Effect of cocaine and related drugs on the uptake of noradrenaline by heart and spleen.

Authors: E MUSCHOLL
Journal: Br J Pharmacol Chemother Date: 1961-06

8 in total

12 in total

5. Dual site of action of phenoxybenzamine in the cat's spleen; blockade of alpha-adrenergic receptors and inhibition of re-uptake of neurally released norepinephrine.

Authors: H Thoenen; A Hürlimann; W Haefely
Journal: Experientia Date: 1964-05-15

6. The potentiation of the responses to noradrenaline and isoprenaline of the guinea-pig isolated tracheal chain preparation by desipramine, cocaine, phentolamine, phenoxybenzamine, guanethidine, metanephrine and cooling.

Authors: R W Foster
Journal: Br J Pharmacol Chemother Date: 1967-11

7. Supersensitivity to catecholamines following guanethidine.

Authors: S D Gokhale; O D Gulati; V V Kelkar
Journal: Br J Pharmacol Chemother Date: 1967-08

8. Inhibition of rabbit intestine mediated by alpha- and beta-adrenoceptors.

Authors: W C Bowman; M T Hall
Journal: Br J Pharmacol Date: 1970-02 Impact factor: 8.739

9. The effects of adrenaline, noradrenaline and isoprenaline on inhibitory alpha- and beta-adrenoceptors in the longitudinal muscle of the guinea-pig ileum.

Authors: H W Kosterlitz; R J Lydon; A J Watt
Journal: Br J Pharmacol Date: 1970-06 Impact factor: 8.739

10. Dissociation of potentiation of isoprenaline by cocaine from inhibition of uptake in cat spleen.

Authors: W J Davidson; I R Innes
Journal: Br J Pharmacol Date: 1970-05 Impact factor: 8.739