Literature DB >> 14081238

ACTINOMYCIN D AS A PROBE FOR NUCLEIC ACID SECONDARY STRUCTURE.

R HASELKORN.   

Abstract

The binding of actinomycin D to DNA results in an increase in the temperature at which thermal dissociation of the DNA occurs. With this enhancement of thermal stability as a criterion for binding, it is shown that complementary RNA and DNA-RNA hybrid do not bind actinomycin D. This result can be interpreted to mean that these polynucleotides have helical conformations which differ from that of DNA.

Entities:  

Keywords:  ACTINOMYCIN; CHEMISTRY; DNA; EXPERIMENTAL LAB STUDY; RNA

Mesh：

Substances：

Year:  1964        PMID： 14081238     DOI： 10.1126/science.143.3607.682

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

1.  Cytoplasmic Z-RNA.

Authors:  D A Zarling; C J Calhoun; C C Hardin; A H Zarling
Journal:  Proc Natl Acad Sci U S A       Date:  1987-09       Impact factor: 11.205

2.  Binding of actinomycin D to DNA: evidence for a nonclassical high-affinity binding mode that does not require GpC sites.

Authors:  J G Snyder; N G Hartman; B L D'Estantoit; O Kennard; D P Remeta; K J Breslauer
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

3.  Inactivity of purified reovirus RNA as a template for E. coli polymerases in vitro.

Authors:  A J Shatkin
Journal:  Proc Natl Acad Sci U S A       Date:  1965-12       Impact factor: 11.205

4.  The structure of a DNA-RNA hybrid.

Authors:  G Milman; R Langridge; M J Chamberlin
Journal:  Proc Natl Acad Sci U S A       Date:  1967-06       Impact factor: 11.205

5.  The interaction of actinomycin with DNA: requirement for the 2-amino group of purines.

Authors:  A Cerami; E Reich; D C Ward; I H Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1967-04       Impact factor: 11.205

6.  Reactions of quinine, chloroquine, and quinacrine with DNA and their effects on the DNA and RNA polymerase reactions.

Authors:  R L O'Brien; J G Olenick; F E Hahn
Journal:  Proc Natl Acad Sci U S A       Date:  1966-06       Impact factor: 11.205

7.  Spectral analysis of the binding of acridine orange to polytene chromosomes.

Authors:  J W MacInnes; R B Uretz
Journal:  Proc Natl Acad Sci U S A       Date:  1966-05       Impact factor: 11.205

8.  Association of actinomycin D and deoxyribodinucleotides as a model for binding of the drug to DNA.

Authors:  T R Krugh
Journal:  Proc Natl Acad Sci U S A       Date:  1972-07       Impact factor: 11.205

9.  PHENETHYL ALCOHOL. I. EFFECT ON MACROMOLECULAR SYNTHESIS OF ESCHERICHIA COLI.

Authors:  H S ROSENKRANZ; H S CARR; H M ROSE
Journal:  J Bacteriol       Date:  1965-05       Impact factor: 3.490

10.  Thermal depolarization of fluorescence from polytene chromosomes stained with acridine orange.

Authors:  J W MacInnes; R B Uretz
Journal:  J Cell Biol       Date:  1967-06       Impact factor: 10.539
  10 in total

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