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Literature DB >> 1407664

Evidence for the presence of excitatory A2 adenosine receptors in the rat hippocampus.

Abstract

The A2 adenosine receptor agonist, CGS 21680 in nanomolar concentrations, reversibly increased in a concentration-dependent manner the amplitude of orthodromically-evoked population spikes recorded from the CA1 pyramidal cell layer of rat hippocampal slices. The adenosine receptor antagonist, 3,7-dimethyl-l-propargylxanthine (DMPX, 10 microM), which has selectivity for A2 adenosine receptors, prevented this excitatory effect of CGS 21680. These results suggest that A2 adenosine receptors are present in the rat hippocampus and that activation of these receptors enhance hippocampal excitability.

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Year: 1992 PMID： 1407664 DOI： 10.1016/0304-3940(92)90467-l

Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046

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Cited

24 in total

1. Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors.

Authors: R A Cunha; B Johansson; M D Constantino; A M Sebastião; B B Fredholm
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1996-02 Impact factor: 3.000

2. Tissue distribution of adenosine receptor mRNAs in the rat.

Authors: A K Dixon; A K Gubitz; D J Sirinathsinghji; P J Richardson; T C Freeman
Journal: Br J Pharmacol Date: 1996-07 Impact factor: 8.739

3. ATP and glutamate are released from separate neurones in the rat medial habenula nucleus: frequency dependence and adenosine-mediated inhibition of release.

Authors: S J Robertson; F A Edwards
Journal: J Physiol Date: 1998-05-01 Impact factor: 5.182

4. Enhanced neuronal damage by co-administration of quinolinic acid and free radicals, and protection by adenosine A2A receptor antagonists.

Authors: W M H Behan; T W Stone
Journal: Br J Pharmacol Date: 2002-03 Impact factor: 8.739

Review 5. Synaptic control of motoneuronal excitability.

Authors: J C Rekling; G D Funk; D A Bayliss; X W Dong; J L Feldman
Journal: Physiol Rev Date: 2000-04 Impact factor: 37.312

6. Effects of adenosine receptors on the synaptic and EPSP-spike components of long-term potentiation and depotentiation in the guinea-pig hippocampus.

Authors: S Fujii; Y Kuroda; K i Ito; K Kaneko; H Kato
Journal: J Physiol Date: 1999-12-01 Impact factor: 5.182

Evidence for the presence of excitatory A2 adenosine receptors in the rat hippocampus.

1. Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors.

2. Tissue distribution of adenosine receptor mRNAs in the rat.

3. ATP and glutamate are released from separate neurones in the rat medial habenula nucleus: frequency dependence and adenosine-mediated inhibition of release.

4. Enhanced neuronal damage by co-administration of quinolinic acid and free radicals, and protection by adenosine A2A receptor antagonists.

Review 5. Synaptic control of motoneuronal excitability.

6. Effects of adenosine receptors on the synaptic and EPSP-spike components of long-term potentiation and depotentiation in the guinea-pig hippocampus.

7. Adenosine receptor-mediated modulation of acetylcholine release from rat striatal synaptosomes.

8. GABA release modified by adenosine receptors in mouse hippocampal slices under normal and ischemic conditions.

9. Tuning and fine-tuning of synapses with adenosine.

10. The role of adenosine in Alzheimer's disease.