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Literature DB >> 14076376

SOME ASPECTS OF HAEMOSTASIS AFTER OPEN-HEART SURGERY.

Abstract

In two groups of patients undergoing extracorporeal circulation with hypothermia, changes were found in the coagulation mechanism which were probably due to the dosage of polybrene administered. The role of heparin and polybrene and the concept of activation of the coagulation mechanism in the production of bleeding after perfusion are discussed.

Entities: Chemical Disease Species

Keywords: AORTIC VALVE STENOSIS; BLOOD CELL COUNT; BLOOD COAGULATION; BLOOD COAGULATION TESTS; BLOOD PLATELETS; DEXTRAN; DRAINAGE; HEART SEPTAL DEFECTS; HEART SURGERY; HEART, MECHANICAL; HEMATOCRIT; HEMOSTASIS; HYPOTHERMIA, INDUCED; MITRAL VALVE STENOSIS; PHYSIOLOGY; PULMONARY VALVE STENOSIS; TETRALOGY OF FALLOT; TOXICOLOGIC REPORT

Mesh：

Substances：
Dextrans
Heparin

Year: 1963 PMID： 14076376 PMCID： PMC480641 DOI： 10.1136/jcp.16.6.569

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

Keyword Cloud
References

9 in total

1. Blood coagulation and vascular integrity: effects of heparin.

Authors: H YOSHIMURA; I DJERASSI
Journal: Blood Date: 1962-11 Impact factor: 22.113

2. Studies on the hemostatic breakdown during massive replacement transfusions.

Authors: M STEFANINI
Journal: Am J Med Sci Date: 1962-09 Impact factor: 2.378

3. Problems in hemostasis during open-heart surgery. II. On the hypercoagulability of blood cardiac bypass.

Authors: H GANS; D L SIEGAL; C W LILLEHEI; W KRIVIT
Journal: Ann Surg Date: 1962-07 Impact factor: 12.969

4. Hematologic problems associated with the use of extracorporeal circulation for cardiovascular surgery.

Authors: I W BROWN; W W SMITH
Journal: Ann Intern Med Date: 1958-11 Impact factor: 25.391

5. Comparison of effects of protamine and polybrene, with special emphasis on the factor VIII (antihemophilic globulin) deficiency induced.

Authors: H A PERKINS; G HARKINS; F GERBODE; M R ROLFS; D J ACRA
Journal: J Clin Invest Date: 1961-08 Impact factor: 14.808

SOME ASPECTS OF HAEMOSTASIS AFTER OPEN-HEART SURGERY.

1. Blood coagulation and vascular integrity: effects of heparin.

2. Studies on the hemostatic breakdown during massive replacement transfusions.

3. Problems in hemostasis during open-heart surgery. II. On the hypercoagulability of blood cardiac bypass.

4. Hematologic problems associated with the use of extracorporeal circulation for cardiovascular surgery.

5. Comparison of effects of protamine and polybrene, with special emphasis on the factor VIII (antihemophilic globulin) deficiency induced.

6. Bleeding after perfusion for open heart surgery. Importance of unneutralized heparin and its proper correction.

7. The effect of stored blood transfusions on the platelet levels in patients undergoing surgical procedures.

8. Diagnosis and control of the hemophilioid states with the partial thromboplastin time (PTT) test.

9. Further studies on hexadimethrine bromide (polybrene)--an antiheparin agent.