Literature DB >> 14076165

OBSERVATIONS ON THE ANTIHYPERTENSIVE AND SEDATIVE EFFECTS OF MEBUTAMATE, MEPROBAMATE AND RESERPINE.

Y MORIN, L TURMEL, H GRANTHAM, J FORTIER.   

Abstract

Mebutamate, a propanediol derivative, has recently been introduced as an antihypertensive agent. In a double-blind, controlled study of 33 patients, the antihypertensive effect of mebutamate was not found to differ significantly from that of a placebo.The psychosedative properties of mebutamate did not differ from those of meprobamate. Reserpine, when given orally, lowered blood pressure and its antihypertensive activity was independent of its sedative properties.

Entities:  

Keywords:  ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE DETERMINATION; HYDROCHLOROTHIAZIDE; HYPNOTICS AND SEDATIVES; MEBUTAMATE; MEPROBAMATE; PLACEBOS; RESERPINE; TOXICOLOGIC REPORT

Mesh：

Substances：

Year:  1963        PMID： 14076165      PMCID： PMC1921910     

Source DB:  PubMed          Journal:  Can Med Assoc J        ISSN： 0008-4409            Impact factor:   8.262


  8 in total

1.  Treatment of hypertension. Introduction.

Authors:  M SPRING
Journal:  N Y State J Med       Date:  1962-05-15

2.  Mebutamate as an antihypertensive agent.

Authors:  J M BRYANT
Journal:  JAMA       Date:  1962-10-06       Impact factor: 56.272

3.  Mebutamate, a new drug for the treatment of hypertension.

Authors:  F B BOHENSKY
Journal:  N Y State J Med       Date:  1962-03-15

4.  Comparative effects of phenaglycodol and meprobamate on anxiety reactions.

Authors:  P ZUKIN; D G ARNOLD; C R KESSLER
Journal:  J Nerv Ment Dis       Date:  1959-08       Impact factor: 2.254

5.  The hypnotic effect of a new propanediol dicarbamate, W 583 (a double blind, double dose study).

Authors:  T BODI; H A LEVY; J H NODINE; J H MOYER
Journal:  Am J Med Sci       Date:  1960-02       Impact factor: 2.378

6.  Observations on the antihypertensive effectiveness of a new propanediol dicarbamate (W-583).

Authors:  C DUARTE; A N BREST; R KODAMA; F NASO; J H MOYER
Journal:  Curr Ther Res Clin Exp       Date:  1960-05

7.  The pharmacological properties of 2-methyl-2-n-propyl-1,3-propanediol dicarbamate (miltown), a new interneuronal blocking agent.

Authors:  F M BERGER
Journal:  J Pharmacol Exp Ther       Date:  1954-12       Impact factor: 4.030

8.  Clinical observations on the antihypertensive response to mebutamate (Capla) in geriatric patients.

Authors:  G A PORTER; M D BAIRD; H E GRISWOLD
Journal:  Am Heart J       Date:  1962-06       Impact factor: 4.749
  8 in total

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