Literature DB >> 14074829

THYMUS: ITS LIMITED ROLE IN THE RECOVERY OF HOMOGRAFT RESPONSE IN IRRADIATED MICE.

M L TYAN, L J COLE, W E DAVIS.   

Abstract

Adult mice subjected to thymectomy or sham thymectomy received lethal irradiation and subsequent protective infusion of syngeneic bone marrow. Thirty days later they received allogeneic and xenogeneic skin grafts. Donors of the xenogeneic grafts were rats. The thymectomized mice rejected the grafts of rat skin only slightly later than the controls did; in contrast, the time of retention of allogeneic grafts was significantly longer in the thymectomized mice.

Entities:  

Keywords:  EXPERIMENTAL LAB STUDY; MICE; RADIATION EFFECTS; SKIN TRANSPLANTATION; SURGERY, OPERATIVE; THYMUS GLAND

Mesh:

Year:  1963        PMID: 14074829     DOI: 10.1126/science.142.3592.584

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  1 in total

1.  Protection of lethally irradiated mice with allogeneic fetal liver cells: influence of irradiation dose on immunologic reconstitution.

Authors:  O Tulunay; R A Good; E J Yunis
Journal:  Proc Natl Acad Sci U S A       Date:  1975-10       Impact factor: 11.205

  1 in total

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