A quantitative model of actin-myosin interaction in skeletal muscle.

Biochemical schemes for the actomyosin ATPase cycle as well as the cooperative regulation of ATPase activity are incorporated into a model of the contractile process of intact muscle. This model is shown to describe accurately the tension developed by skinned muscle fibers in the absence of Ca. This work adds to the evidence that the extrapolation of results from purified protein systems to intact muscle may be valid. Extensions to the case of Ca-activated tensions are discussed.