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Literature DB >> 14070376

BASIC BIOCHEMICAL EFFECTS AND MECHANISM OF ACTION OF 6-THIOGUANINE.

Abstract

Entities: Chemical

Keywords: CARBON ISOTOPES; DNA, NEOPLASM; EXPERIMENTAL LAB STUDY; GUANINE; MAMMARY NEOPLASMS, EXPERIMENTAL; METABOLISM; MICE; PHARMACOLOGY; RNA, NEOPLASM; SULFHYDRYL COMPOUNDS

Mesh：

Substances：

Year: 1963 PMID： 14070376

Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701

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Cited

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18 in total

1. Structural effect of the anticancer agent 6-thioguanine on duplex DNA.

Authors: Jen Bohon; Carlos R de los Santos
Journal: Nucleic Acids Res Date: 2003-02-15 Impact factor: 16.971

2. Interference of 6-mercaptopurine riboside, 6-methylmercaptopurine riboside and azathioprine with the morphogenetic differentiation of mouse extremities in vivo and in organ culture.

Authors: D Neubert; U Lessmöllmann; N Hinz; I Dillmann; G Fuchs
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1977-06 Impact factor: 3.000

3. Synthesis and biological evaluation of some phosphate triester derivatives of the anti-viral drug AraA.

Authors: C McGuigan; S M Tollerfield; P A Riley
Journal: Nucleic Acids Res Date: 1989-08-11 Impact factor: 16.971

4. Synthesis and biological evaluation of some phosphate triester derivatives of the anti-cancer drug araC.

Authors: B C Jones; C McGuigan; P A Riley
Journal: Nucleic Acids Res Date: 1989-09-25 Impact factor: 16.971

5. Clinical pharmacology of oral thioguanine in acute myelogenous leukemia.

Authors: L W Brox; L Birkett; A Belch
Journal: Cancer Chemother Pharmacol Date: 1981 Impact factor: 3.333

6. Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment.

Authors: Gianluigi Zaza; Meyling Cheok; Wenjian Yang; John C Panetta; Ching-Hon Pui; Mary V Relling; William E Evans
Journal: Blood Date: 2005-05-19 Impact factor: 22.113

BASIC BIOCHEMICAL EFFECTS AND MECHANISM OF ACTION OF 6-THIOGUANINE.

1. Structural effect of the anticancer agent 6-thioguanine on duplex DNA.

2. Interference of 6-mercaptopurine riboside, 6-methylmercaptopurine riboside and azathioprine with the morphogenetic differentiation of mouse extremities in vivo and in organ culture.

3. Synthesis and biological evaluation of some phosphate triester derivatives of the anti-viral drug AraA.

4. Synthesis and biological evaluation of some phosphate triester derivatives of the anti-cancer drug araC.

5. Clinical pharmacology of oral thioguanine in acute myelogenous leukemia.

6. Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment.

7. Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine.

8. Guanine analogues enhance antisense oligonucleotide-induced exon skipping in dystrophin gene in vitro and in vivo.

9. Effects of 6-thioguanine and S6-methylthioguanine on transcription in vitro and in human cells.

10. Mutagenic and cytotoxic properties of 6-thioguanine, S6-methylthioguanine, and guanine-S6-sulfonic acid.