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Literature DB >> 14068224

INHIBITION OF ADHESIVENESS AND AGGREGATION OF DISSOCIATED CELLS BY INHIBITORS OF PROTEIN AND RNA SYNTHESIS.

Abstract

Mutual adhesiveness and aggregation of dissociated embryonic retina cells in suspension cultures are suppressed rapidly and reversibly by puromycin, an inhibitor of RNA-dependent protein synthesis; and at a slower rate, irreversibly, by actinomycin D, an inhibitor of RNA formation. The results imply that biosynthetic processes are involved in the mechanism of reattachment of these cells.

Entities: Chemical Disease

Keywords: ACTINOMYCIN; ANTIBIOTICS; CHICK EMBRYO; CYTOLOGY; EXPERIMENTAL LAB STUDY; PHARMACOLOGY; PROTEIN METABOLISM; PUROMYCIN; RETINA; RNA

Mesh：

Substances：

Year: 1963 PMID： 14068224 DOI： 10.1126/science.142.3595.1070

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

12 in total

4. Aggregative properties of different cell types of the fresh-water spongeEphydatia fluviatilis isolated on ficoll gradients.

Authors: D De Sutter; G Van de Vyver
Journal: Wilehm Roux Arch Dev Biol Date: 1977-06

10. Cell-surface interactions: differential inhibition by proflavine of embryonic cell aggregation and production of specific cell-aggregating factor.

Authors: R E Hausman; A A Moscona
Journal: Proc Natl Acad Sci U S A Date: 1973-11 Impact factor: 11.205

INHIBITION OF ADHESIVENESS AND AGGREGATION OF DISSOCIATED CELLS BY INHIBITORS OF PROTEIN AND RNA SYNTHESIS.

1. Isolation of retina-specific cell-aggregating factor from membranes of embryonic neural retina tissue.

2. Intercellular adhesion : I. A quantitative assay for measuring the rate of adhesion.

3. [Influence of inhibitors of RNA and protein synthesis and inductors upon cell affinity of amphibian tissues].

4. Aggregative properties of different cell types of the fresh-water spongeEphydatia fluviatilis isolated on ficoll gradients.

5. The mechanism of aggregation of neural retina cellsin vitro.

6. Histotypic reaggregation of dissociated imaginal disc cells ofDrosophila melanogaster culturedin vivo.

7. [Adhesion of algal spores].

8. Molecular coding of information in the nervous system.

9. [Inhibition of aggregation of dissociated embryonic Amphibian cells by inhibitors of protein and RNA synthesis].

10. Cell-surface interactions: differential inhibition by proflavine of embryonic cell aggregation and production of specific cell-aggregating factor.