Literature DB >> 14061195

GENETIC DIFFERENCES IN ANTIBODY PRODUCTION TO DETERMINANT GROUPS ON INSULIN.

E R ARQUILLA, J FINN.   

Abstract

Highly inbred strain 2 guinea pigs can produce antibodies to portions of the insulin molecule to which strain 13 guinea pigs cannot produce antibodies. Such differences were not observable within either strain. Consequently it is probable that genetic factors regulate antibody production with respect to the determinant groups toward which antibodies are directed.

Entities:  

Keywords:  EXPERIMENTAL LAB STUDY; GENETICS; GUINEA PIGS; INSULIN ANTIBODIES

Mesh：

Substances：

Year:  1963        PMID： 14061195     DOI： 10.1126/science.142.3590.400

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  The experimental generation of antibodies to alpha-melanocyte stimulating hormone and adrenocorticotropic hormone.

Authors:  J McGuire; R McGill; S Leeman; T Goodfriend
Journal:  J Clin Invest       Date:  1965-10       Impact factor: 14.808

Review 2.  Genetic differences of combining sites of insulin antibodies and importance of C-terminal portion of the A chain to biological and immunological activity of insulin.

Authors:  E R Arquilla; H Ooms; J Finn
Journal:  Diabetologia       Date:  1966-06       Impact factor: 10.122

Review 3.  Chemical markers of transplantation individuality solubilized with sonic energy.

Authors:  B D Kahan; R A Reisfeld
Journal:  Bacteriol Rev       Date:  1971-03

4.  Insulin autoantibody polymorphisms with greater discrimination for diabetes in humans.

Authors:  T Wilkin; I Mirza; M Armitage; C Casey; L Scott-Morgan
Journal:  Diabetologia       Date:  1988-09       Impact factor: 10.122

5.  The acetylation of insulin.

Authors:  D G Lindsay; S Shall
Journal:  Biochem J       Date:  1971-03       Impact factor: 3.857

6.  Genetic control of combining sites of insulin antibodies produced by guinea pigs.

Authors:  E R Arquilla; J Finn
Journal:  J Exp Med       Date:  1965-10-01       Impact factor: 14.307

7.  H-2-linked genetic control of immune responsiveness to ovalbumin and ovomucoid.

Authors:  N M Vaz; J M Phillips-Quagliata; B B Levine; E M Vaz
Journal:  J Exp Med       Date:  1971-11-01       Impact factor: 14.307

8.  Genetic control of the antibody response. I. Demonstration of determinant-specific differences in response to synthetic polypeptide antigens in two strains of inbred mice.

Authors:  H O McDevitt; M Sela
Journal:  J Exp Med       Date:  1965-09-01       Impact factor: 14.307

9.  The genetic control of antibody specificity.

Authors:  E Mozes; H O McDevitt; J C Jaton; M Sela
Journal:  J Exp Med       Date:  1969-12-01       Impact factor: 14.307
  9 in total

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