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Literature DB >> 14058262

PANCREATIC REPLACEMENT THERAPY IN THE TREATMENT OF PANCREATIC STEATORRHOEA.

Abstract

The effect of a whole pancreas preparation (Viokase) has been investigated in 11 patients with pancreatic steatorrhoea and in five patients with steatorrhoea due to other causes. The appearance of the stool, faecal fat, and stool and blood radioactivity after a given dose of I(131) triolein (Raolein) were employed in assessing the response to Viokase therapy. Pancreatic steatorrhoea was considerably improved in the majority of patients, and showed some improvement in the remainder. Viokase appeared to be of limited value in the treatment of post-gastrectomy steatorrhoea, and failed to influence fat absorption in steatorrhoea due to disorder of the small intestine.

Entities: Disease Species

Keywords: IODINE ISOTOPES, DIAGNOSTIC; PANCREATIC EXTRACTS; PANCREATITIS; SPRUE; TRIOLEIN

Mesh：

Substances：

Year: 1963 PMID： 14058262 PMCID： PMC1413448 DOI： 10.1136/gut.4.3.217

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

9 in total

1. I 131-labeled fat and pancreatin as a differential absorption test in patients with steatorrhea.

Authors: A A POLACHEK; R F WILLIARD
Journal: Ann Intern Med Date: 1960-06 Impact factor: 25.391

2. Studies on postgastrectomy steatorrhea using radioactive triolein and oleic acid.

Authors: W W SHINGLETON; J K ISLEY; R D FLOYD; A P SANDERS; G J BAYLIN; R W POSTLETHWAIT; J M RUFFIN
Journal: Surgery Date: 1957-07 Impact factor: 3.982

3. Pancreaticoduodenectomy for chronic relapsing pancreatitis; metabolic defects created by total and subtotal ablations.

Authors: P H JORDAN; M I GROSSMAN
Journal: AMA Arch Surg Date: 1957-06

4. The radio-iodinated triolein test for steatorrhea.

Authors: M I GROSSMAN; P H JORDAN
Journal: Gastroenterology Date: 1958-05 Impact factor: 22.682

5. The diagnosis of pancreatic disease.

Authors: I N MARKS; S L TOMPSETT
Journal: Q J Med Date: 1958-07

6. Experience with resection of the pancreas in the treatment of chronic relapsing pancreatitis.

Authors: J D BRIGGS; P H JORDAN; W P LONGMIRE
Journal: Ann Surg Date: 1956-10 Impact factor: 12.969

7. Metabolism in surgical patients. III. Effect of drugs and dietary procedures on fat and nitrogen metabolism in totally gastrectomized patients.

Authors: O BODANSKY; H T RANDALL; M K SCHWARTZ
Journal: Surgery Date: 1956-10 Impact factor: 3.982

8. Nutrition following total gastrectomy, with particular reference to fat and protein assimilation.

Authors: T C EVERSON
Journal: Int Abstr Surg Date: 1952-09

9. Effect of intestinal hormones on I-131-triolein absorption in subtotal gastrectomy patients and intubated normal persons.

Authors: J H JOHNSON; R R HORSWELL; M P TYOR; E E OWEN; J M RUFFIN
Journal: Gastroenterology Date: 1961-09 Impact factor: 22.682

9 in total

8 in total

1. THE RADIOISOTOPE LABORATORY IN CLINICAL GASTROENTEROLOGY.

Authors: M P TYOR
Journal: Am J Dig Dis Date: 1964-08

2. The treatment of pancreatic exocrine insufficiency. 3. The effects of pancreatic ductal ligation and oral pancreatic enzyme supplements on fecal lipid excretion in the dog.

Authors: F W Pairent; J E Trapnell; J M Howard
Journal: Ann Surg Date: 1969-11 Impact factor: 12.969

3. Pancreatic extracts.

Authors:
Journal: Br Med J Date: 1970-04-18

4. Treatment of pancreatic exocrine insufficiency. II. Effects on fat absorption of pancreatic lipase and fifteen commercial pancreatic supplements as measured by I-131 tagged triolein in the dog.

Authors: B B Giulian; H Mitsuoka; A O Mansfield; J E Trapnell; J A Seddon; J M Howard
Journal: Ann Surg Date: 1967-04 Impact factor: 12.969

5. Incidence and severity of nutritional deficiency states in chronic exocrine pancreatic insufficency: comparison with nontropical sprue.

Authors: W B Evans; E E Wollaeger
Journal: Am J Dig Dis Date: 1966-08

6. Pancreatic enzyme replacement therapy. Importance of gastric acid secretion, H2-antagonists, and enteric coating.

Authors: F Marotta; S J O'Keefe; I N Marks; A Girdwood; G Young
Journal: Dig Dis Sci Date: 1989-03 Impact factor: 3.199

7. Differential diagnosis of maldigestion and malabsorption of fat. I. Comparison of the radioactivity of triglyceride and non-esterified fatty acid in fecal fat using purified 131I-triolein.

Authors: K Hatakeyama; S Koyama
Journal: Jpn J Surg Date: 1981

8. Biochemical vitamin E deficiency in chronic pancreatitis.

Authors: I Kalvaria; D Labadarios; G S Shephard; L Visser; I N Marks
Journal: Int J Pancreatol Date: 1986-07

8 in total