Literature DB >> 14056708

NOREPINEPHRINE AND 3,4DIHYDROXYPHENETHYLAMINE TURNOVER IN GUINEA PIG BRAIN IN VIVO.

S UDENFRIEND, P ZALTZMAN-NIRENBERG.   

Abstract

By administering C(14)-la-beled tyrosine or H(3)-labeled 3,4-dihy-droxyphenylalanine to guinea pigs it has been possible to achieve sufficient labeling of the norepinephrine and dopamine in the brain to permit measurement of their turnover rates. The half-life of brain dopamine was about 2.5 hours. The half-life of norepinephrine was about 4 hours, suggesting a rate of synthesis of at least 0.03 to 0.04, microg/g per hr or 2.4 microg/day for the whole guinea pig brain.

Entities:  

Keywords:  BRAIN; CARBON ISOTOPES; DOPAMINE; EXPERIMENTAL LAB STUDY; GUINEA PIGS; METABOLISM; NOREPINEPHRINE; TRITIUM; TYROSINE

Mesh：

Substances：

Year:  1963        PMID： 14056708     DOI： 10.1126/science.142.3590.394

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  12 in total

1.  MODIFICATION BY DRUGS OF THE METABOLISM OF 3,4-DIHYDROXYPHENYLETHYLAMINE, NORADRENALINE AND 5-HYDROXYTRYPTAMINE IN THE BRAIN.

Authors:  R LAVERTY; D F SHARMAN
Journal:  Br J Pharmacol Chemother       Date:  1965-06

2.  Increased turnover of arterial collagen in hypertensive rats.

Authors:  R Nissen; G J Cardinale; S Udenfriend
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

3.  The regulation of norepinephrine synthesis in sympathetic nerves: effect of nerve stimulation, cocaine, and catecholamine-releasing agents.

Authors:  A Alousi; N Weiner
Journal:  Proc Natl Acad Sci U S A       Date:  1966-11       Impact factor: 11.205

4.  Effects of chronic amphetamine intoxication on the accumulation in the rat brain of labelled catecholamines synthesized from circulating tyrosine- 14 C and Dopa- 3 H.

Authors:  T Lewander
Journal:  Naunyn Schmiedebergs Arch Pharmakol       Date:  1971

5.  Influence of drugs on catecholamine metabolism in brain as studied by 14C-tyrosine.

Authors:  H Nybäck; G Sedvall
Journal:  Br J Pharmacol       Date:  1968-09       Impact factor: 8.739

6.  Aspects of the biogenic amine-depleting activity of ethyl 3-acetamido-4H-pyrrolo-[3,4-c]isoxazole-5(6H)-carboxylate in the rat.

Authors:  W Lippmann; M Wishnick
Journal:  Br J Pharmacol Chemother       Date:  1968-06

7.  Distribution and metabolism of DL-3,4-dihydroxy[2-14C]-phenylalanine in rat tissues.

Authors:  K F Gey; A Pletscher
Journal:  Biochem J       Date:  1964-08       Impact factor: 3.857

8.  Observations on the accumulation of noradrenaline in the proximal and distal parts of peripheral adrenergic nerves after compression.

Authors:  A Dahlström
Journal:  J Anat       Date:  1965-10       Impact factor: 2.610

9.  The uptake and release of radioactive noradrenaline by the splenic nerves of cats.

Authors:  J S Gillespie; S M Kirpekar
Journal:  J Physiol       Date:  1966-11       Impact factor: 5.182

10.  Catecholamine turnover in normotensive and hypertensive man: effects of antiadrenergic drugs.

Authors:  V DeQuattro; A Sjoerdsma
Journal:  J Clin Invest       Date:  1968-10       Impact factor: 14.808
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.