Literature DB >> 14056707

POLYPEPTIDE CHAINS OF RABBIT GAMMAGLOBULIN.

P A SMALL, J E KEHN, M E LAMM.   

Abstract

Rabbit gamma globulin has been extensively reduced, and its polypeptide chains separated by gel filtration on Sephadex G-200 in SM guanidine hydrochloride. The larger H (or A) chains make up two-thirds of the molecule and have a molecular weight of approximately 55,000 each. The smaller L (or B) chains account for the other one-third and have a molecular weight of approximately 25,000 each. The data are consistent with a model of the gamma globulin molecule that has two H and two L chains.

Entities:  

Keywords:  CHROMATOGRAPHY; EXPERIMENTAL LAB STUDY; GAMMA GLOBULIN; GUANIDINES; PEPTIDES; RABBITS

Mesh：

Substances：

Year:  1963        PMID： 14056707     DOI： 10.1126/science.142.3590.393

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  11 in total

1.  A MODEL FOR THE 7S ANTIBODY MOLECULE.

Authors:  G M EDELMAN; J A GALLY
Journal:  Proc Natl Acad Sci U S A       Date:  1964-05       Impact factor: 11.205

2.  RECOMBINATION OF ANTIBODY POLYPEPTIDE CHAINS IN THE PRESENCE OF ANTIGEN.

Authors:  H METZGER; M MANNIK
Journal:  J Exp Med       Date:  1964-11-01       Impact factor: 14.307

3.  Isolation of purified H and L polypeptide chains from guinea-pig gamma-2-immunoglobulin after mild reduction.

Authors:  M E Lamm; V Nussenzweig; B Benacerraf
Journal:  Immunology       Date:  1966-04       Impact factor: 7.397

4.  The molecular basis of antibody formation: a paradox.

Authors:  W J Dreyer; J C Bennett
Journal:  Proc Natl Acad Sci U S A       Date:  1965-09       Impact factor: 11.205

5.  A model for colostral IgA.

Authors:  R Hong; B Pollara; R A Good
Journal:  Proc Natl Acad Sci U S A       Date:  1966-08       Impact factor: 11.205

6.  Comparison of the cysteine-containing peptides from rabbit anti-tobacco mosaic virus antibody and non-specific immunoglobulin G by peptide mapping.

Authors:  C Szpirer
Journal:  Immunology       Date:  1971-02       Impact factor: 7.397

7.  Phylogenetic origins of antibody structure. II. Immunoglobulins in the primary immune response of the bullfrog, Rana catesbiana.

Authors:  J Marchalonis; G M Edelman
Journal:  J Exp Med       Date:  1966-11-01       Impact factor: 14.307

8.  RECONSTITUTION OF 7S MOLECULES FROM L AND H POLYPEPTIDE CHAINS OF ANTIBODIES AND GAMMA-GLOBULINS.

Authors:  D E OLINS; G M EDELMAN
Journal:  J Exp Med       Date:  1964-05-01       Impact factor: 14.307

9.  Studies on rabbit lymphocytes in vitro. V. The induction of blast transformation with sheep antisera to rabbit IgG subunits.

Authors:  S Sell
Journal:  J Exp Med       Date:  1967-02-01       Impact factor: 14.307

10.  Phylogenetic origins of antibody structure. 3. Antibodies in the primary immune response of the sea lamprey, Petromyzon marinus.

Authors:  J J Marchalonis; G M Edelman
Journal:  J Exp Med       Date:  1968-05-01       Impact factor: 14.307
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