| Literature DB >> 1404667 |
Y Takahashi1, N Ishii, T F Lue, E A Tanagho.
Abstract
We investigated the hemodynamic effects of intracavernous injection of adenosine on canine penile erection. In all ten dogs studied, adenosine induced a dose-dependent increase of intracavernous pressure (ICP). Adenosine (0.67 to 15 micrograms/kg., B.W.) increased arterial blood flow by 83 to 325 percent above baseline levels and also increased venous resistance, which resulted in a full erection (ICP = 80 to 140 cm. H2O) for one to 7 minutes. The repeatability of the adenosine effect was confirmed in eight dogs. We found that adenosine, by virtue of its smooth muscle relaxation properties, can induce a dose-dependent increase of ICP and cause a full erection in dogs.Entities:
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Year: 1992 PMID： 1404667 DOI： 10.1016/s0022-5347(17)36901-x
Source DB: PubMed Journal: J Urol ISSN： 0022-5347 Impact factor: 7.450