Literature DB >> 14043353

ACTINOMYCIN D EFFECTS IN FROG EMBRYOS: EVIDENCE FOR SEQUENTIAL SYNTHESIS OF DNA-DEPENDENT RNA.

R A FLICKINGER.   

Abstract

Early gastrulae of Rana pipiens exposed to actinomycin D for 2 days were then cultured in saline. The resulting larvae were immotile; histological examination revealed impaired development of axial nerve and muscle tissues, but normal differentiation of sensory, pronephric, heart, and digestive tissues; this suggests sequential synthesis of the different tissue-specific molecules of DNA-dependent RNA.

Entities:  

Keywords:  ACTINOMYCIN; CULTURE MEDIA; DNA; EMBRYO; EXPERIMENTAL LAB STUDY; FROGS; METABOLISM; RNA; SODIUM CHLORIDE; TISSUE CULTURE

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Substances：

Year:  1963        PMID： 14043353     DOI： 10.1126/science.141.3585.1063

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  ACTINOMYCIN D INHIBITION OF CELL DIFFERENTIATION IN THE AMPHIBIAN SUCKER.

Authors:  R M EAKIN
Journal:  Z Zellforsch Mikrosk Anat       Date:  1964-06-12

2.  THE ABILITY OF DNA AND CHROMATIN OF DEVELOPING FROG EMBRYOS TO PRIME FOR RNA POLYMERASE-DEPENDENT RNA SYNTHESIS.

Authors:  R A FLICKINGER; S J COWARD; M MIYAGE; C MOSER; E ROLLINS
Journal:  Proc Natl Acad Sci U S A       Date:  1965-04       Impact factor: 11.205

3.  Inhibition of development ofPlanorbis exustus by chloramphenicol.

Authors:  Gajanan V Sherbet; M S Lakshmi
Journal:  Wilhelm Roux Arch Entwickl Mech Org       Date:  1964-07

4.  The effect of puromycin on the early cleavage cycles and morphogenesis of the pond snailLymnaea stagnalis.

Authors:  Elida K Boon-Niermeijer
Journal:  Wilehm Roux Arch Dev Biol       Date:  1975-03

5.  Alleviation of the toxicity of actinomycin D by uridine and thymidine on the morphogenesis of chick embryos cultivated in vitro.

Authors:  S M Katdare; L Mulherkar
Journal:  Experientia       Date:  1972-06-15

6.  On the action of chromomycin on the eggs and embryos of Ciona intestinalis.

Authors:  R L Brachmachary; G Reverberi
Journal:  Experientia       Date:  1964-11-15

7.  [The direct action of actinomycin D upon the encephalon of the chick embryo. Experimental obtainment of cyclopia].

Authors:  F Diethelm; J Schowing
Journal:  Wilhelm Roux Arch Entwickl Mech Org       Date:  1974-06
  7 in total

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