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Literature DB >> 14042936

ACTION OF DIHYDROSTREPTOMYCIN AND ANTAGONISM BY CATIONS.

Abstract

Bragg, P. D. (University of British Columbia, Vancouver, Canada) and W. J. Polglase. Action of dihydrostreptomycin and antagonism by cations. J. Bacteriol. 85:590-594. 1963.-A number of antibiotics including dihydrostreptomycin inhibited the induction of beta-galactosidase in Escherichia coli and, except in the case of chloramphenicol, magnesium antagonized the inhibition. Of the antibiotics tested, only dihydrostreptomycin caused formation of pyruvate from the oxidation of glucose. Under similar conditions, inhibitors of terminal respiration (cyanide, azide, amobarbital) also caused formation of pyruvate. Magnesium and the polyamines, putrescine and spermidine, were observed to antagonize dihydrostreptomycin in systems in which the antibiotic showed an inhibitory action.

Entities: Chemical Disease Species

Keywords: AMOBARBITAL; ANTIBIOTICS; CHLORAMPHENICOL; CYANIDES; DIHYDROSTREPTOMYCIN; ESCHERICHIA COLI; GALACTOSIDASE; GLUCOSE; IONS; MAGNESIUM; METABOLISM; NEOMYCIN; PENICILLIN; PHARMACOLOGY; PYRUVATES; QUINOLINES

Mesh：

Substances：

Year: 1963 PMID： 14042936 PMCID： PMC278187 DOI： 10.1128/jb.85.3.590-594.1963

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

14 in total

ACTION OF DIHYDROSTREPTOMYCIN AND ANTAGONISM BY CATIONS.

1. Mechanism of streptomycin action on bacteria: a unitary hypothesis.

2. Polypeptide synthesis with ribosomes from streptomycin-resistant and dependent E. coli.

3. Inhibition of polypeptide synthesis by streptomycin.

4. The action of streptomycin. VI. A new metabolic intermediate.

5. Inhibition of the anaerobic pyruvate metabolism of Escherichia coli by dihydrostreptomycin.

6. Mode of action of antibiotics. II. Specificity of action of antimycin A and ascosin.

7. Characteristics and stabilization of DNAase-sensitive protein synthesis in E. coli extracts.

8. A common site of action of polyamines and streptomycin.

9. The beta-d-galactosidase of Escherichia coli, strain K-12.

10. Extracellular metabolites of streptomycin mutants of Escherichia coli.

1. PRECIPITATION OF ESCHERICHIA COLI RIBOSOMES WITH DIHYDROSTREPTOMYCIN.

2. Evidence for a magnesium pump in Bacillus cereus T.

3. Protection of Mycobacterium smegmatis from Ethambutol and Streptomycin Inhibition by MgSO(4) and Polyamines.

4. EFFECT OF DIHYDROSTREPTOMYCIN ON TETRAZOLIUM DYE REDUCTION IN ESCHERICHIA COLI.

5. Nonspecific ionic inhibition of ethambutol binding by Mycobacterium smegmatis.

6. INHIBITION OF OXIDATIVE PHOSPHORYLATION IN ESCHERICHIA COLI BY DIHYDROSTREPTOMYCIN.

7. ELECTRON-TRANSPORT COMPONENTS OF STREPTOMYCIN-DEPENDENT ESCHERICHIA COLI.