| Literature DB >> 1404236 |
R N Comber1, R C Reynolds, J D Friedrich, R A Manguikian, R W Buckheit, J W Truss, W M Shannon, J A Secrist.
Abstract
A series of 5,5-disubstituted hydantoin derivatives was synthesized by alkylating 5,5-bis(mercaptomethyl)-2,4-imidazolidinedione (3) with various halomethylaromatic or halomethylheteroaromatic precursors, or by using the Buchener-Berg procedure on the required ketone. When evaluated for their ability to inhibit HIV-induced cell killing and virus production in CEM or MT-2 cells only compounds 2, 4n, 4o, and 4i demonstrated modest activity, the latter with an IC50 = 53 microM.Entities:
Mesh：
Substances：
Year: 1992 PMID： 1404236 DOI： 10.1021/jm00097a014
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446