Literature DB >> 14032825

Teratogenic effects of meclizine hydrochloride on the rat.

C T KING.   

Abstract

Congenital malformations were induced in the offspring of pregnant Sprague-Dawley rats by the admninistration of relatively large doses of meclizine hydrochloride (Bonine). The critical period of gestation for administration was from the 12th to 15th day. Anomalies were produced in the tongue, palatal closure, mouth, lower jaw, vertebrae and limbs.

Entities:  

Keywords:  ABNORMALITIES; MECLIZINE

Mesh：

Substances：

Year:  1963        PMID： 14032825     DOI： 10.1126/science.141.3578.353

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  Teratogenic risk of drugs used in early pregnancy.

Authors:  J Ruedy
Journal:  Can Fam Physician       Date:  1984-10       Impact factor: 3.275

2.  Mammillo-hypophyseal duplication (diplo-mammillo-hypophysis).

Authors:  F Tagliavini; G Pilleri
Journal:  Acta Neuropathol       Date:  1986       Impact factor: 17.088

3.  Ultrastructures of glosso-palatal fusion after treatment of meclozine-hydrochloride.

Authors:  M Mato; Y Uchiyama
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1975-12-29

4.  Studies on a site-specific cleft palate teratogen. The toxic extract from Indigofera spicata Forssk.

Authors:  J H Pearn
Journal:  Br J Exp Pathol       Date:  1967-12

5.  Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.

Authors:  Liam M Casey; Yu Lan; Eui-Sic Cho; Kathleen M Maltby; Thomas Gridley; Rulang Jiang
Journal:  Dev Dyn       Date:  2006-07       Impact factor: 3.780

6.  Delivery outcome after the use of meclozine in early pregnancy.

Authors:  Bengt Källén; Isabelle Mottet
Journal:  Eur J Epidemiol       Date:  2003       Impact factor: 8.082

7.  Use of antihistamine medications during early pregnancy and isolated major malformations.

Authors:  Suzanne M Gilboa; Matthew J Strickland; Andrew F Olshan; Martha M Werler; Adolfo Correa
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2009-02

8.  Congenital bilateral syngnathia and tracheoesophageal fistula: A rare presentation.

Authors:  Ankit Khasgiwala; Sagar Jangam; Shashi Sharma; Vilas Newaskar
Journal:  Contemp Clin Dent       Date:  2016 Oct-Dec
  8 in total

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