Effectiveness of locally inoculated antirabies serum and gamma-globulin in rabies infection of mice.

In an attempt to determine the specific local action of antirabies serum and antirabies gamma-globulin preparations in vivo, experiments were carried out on mice infected with fixed rabies virus in the pad of the foot and then given inoculations of either of these preparations in the same and in the opposite foot at various intervals thereafter.Good evidence was obtained of the local protective effect of antirabies serum and, to a lesser degree, of antirabies gamma-globulin when inoculated one hour after infection. Some protection was also apparent when the inoculations were made up to three hours after infection, but none could be demonstrated at six hours.