Literature DB >> 1402665

Bone marrow transplantation as a strategy for treatment of non-insulin-dependent diabetes mellitus in KK-Ay mice.

S Than1, H Ishida, M Inaba, Y Fukuba, Y Seino, M Adachi, H Imura, S Ikehara.   

Abstract

The effects of allogeneic bone marrow transplantation (BMT) on non-insulin-dependent diabetes mellitus (NIDDM) were examined using KK-Ay mice. KK-Ay mice reconstituted with KK-Ay bone marrow cells showed glycosuria, hyperinsulinemia, and hyperlipidemia. However, KK-Ay mice (H-2b) that had been lethally irradiated (9.0 Gy) and then reconstituted with T cell-depleted bone marrow cells from normal BALB/c mice (H-2d) showed negative urine sugar with decreases in serum insulin and lipid levels 4 mo after BMT. Morphological recovery of islets and glomeruli was also noted after allogeneic BMT. These findings suggest that BMT can be used to treat not only a certain type of NIDDM but also its complications such as hyperlipidemia and diabetic nephropathy.

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Year:  1992        PMID： 1402665      PMCID： PMC2119408          DOI： 10.1084/jem.176.4.1233

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  10 in total

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Journal:  Diabetologia       Date:  1974-11       Impact factor: 10.122

2.  Glomerular changes in mice with spontaneous hereditary diabetes.

Authors:  H Wehner; D Höhn; U Faix-Schade; H Huber; P Walzer
Journal:  Lab Invest       Date:  1972-09       Impact factor: 5.662

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Authors:  A Shino; H Iwatsuka
Journal:  Endocrinol Jpn       Date:  1970-12

4.  Studies on a diabetic (KK) strain of the mouse.

Authors:  M Nakamura; K Yamada
Journal:  Diabetologia       Date:  1967-04       Impact factor: 10.122

5.  Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays.

Authors:  B Desbuquois; G D Aurbach
Journal:  J Clin Endocrinol Metab       Date:  1971-11       Impact factor: 5.958

6.  Treatment of type 1 diabetes mellitus in non-obese diabetic mice by transplantation of allogeneic bone marrow and pancreatic tissue.

Authors:  R Yasumizu; K Sugiura; H Iwai; M Inaba; S Makino; T Ida; H Imura; Y Hamashima; R A Good; S Ikehara
Journal:  Proc Natl Acad Sci U S A       Date:  1987-09       Impact factor: 11.205

7.  Prevention of type I diabetes in nonobese diabetic mice by allogenic bone marrow transplantation.

Authors:  S Ikehara; H Ohtsuki; R A Good; H Asamoto; T Nakamura; K Sekita; E Muso; Y Tochino; T Ida; H Kuzuya
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205

8.  Pathogenesis of NIDDM. A balanced overview.

Authors:  R A DeFronzo; R C Bonadonna; E Ferrannini
Journal:  Diabetes Care       Date:  1992-03       Impact factor: 19.112

9.  Rationale for bone marrow transplantation in the treatment of autoimmune diseases.

Authors:  S Ikehara; R A Good; T Nakamura; K Sekita; S Inoue; M M Oo; E Muso; K Ogawa; Y Hamashima
Journal:  Proc Natl Acad Sci U S A       Date:  1985-04       Impact factor: 11.205

10.  (NZW x BXSB)F1 mouse. A new animal model of idiopathic thrombocytopenic purpura.

Authors:  N Oyaizu; R Yasumizu; M Miyama-Inaba; S Nomura; H Yoshida; S Miyawaki; Y Shibata; S Mitsuoka; K Yasunaga; S Morii
Journal:  J Exp Med       Date:  1988-06-01       Impact factor: 14.307
  10 in total
  14 in total

1.  Bone marrow transplantation temporarily improves pancreatic function in streptozotocin-induced diabetes: potential involvement of very small embryonic-like cells.

Authors:  Yiming Huang; Magda Kucia; Lala-Rukh Hussain; Yujie Wen; Hong Xu; Jun Yan; Mariusz Z Ratajczak; Suzanne T Ildstad
Journal:  Transplantation       Date:  2010-03-27       Impact factor: 4.939

2.  Prevention of graft-versus-host disease by intrabone marrow injection of donor T cells: involvement of bone marrow stromal cells.

Authors:  T Miyake; M Inaba; J Fukui; Y Ueda; N Hosaka; Y Kamiyama; S Ikehara
Journal:  Clin Exp Immunol       Date:  2008-02-25       Impact factor: 4.330

3.  Alterations in basal and glucose-stimulated voltage-dependent Ca2+ channel activities in pancreatic beta cells of non-insulin-dependent diabetes mellitus GK rats.

Authors:  S Kato; H Ishida; Y Tsuura; K Tsuji; M Nishimura; M Horie; T Taminato; S Ikehara; H Odaka; I Ikeda; Y Okada; Y Seino
Journal:  J Clin Invest       Date:  1996-06-01       Impact factor: 14.808

4.  Primary role of interleukin-1 alpha and interleukin-1 beta in lipopolysaccharide-induced hypoglycemia in mice.

Authors:  Senri Oguri; Katsutoshi Motegi; Yoichiro Iwakura; Yasuo Endo
Journal:  Clin Diagn Lab Immunol       Date:  2002-11

5.  Successful modulation of type 2 diabetes in db/db mice with intra-bone marrow--bone marrow transplantation plus concurrent thymic transplantation.

Authors:  Ming Li; Nader G Abraham; Luca Vanella; Yuming Zhang; Muneo Inaba; Naoki Hosaka; Sho-Ichi Hoshino; Ming Shi; Yoko Miyamoto Ambrosini; M Eric Gershwin; Susumu Ikehara
Journal:  J Autoimmun       Date:  2010-12       Impact factor: 7.094

6.  Treatment of autoimmune diseases in MRL/lpr mice by allogenic bone marrow transplantation plus adult thymus transplantation.

Authors:  N Hosaka; T Ryu; T Miyake; W Cui; T Nishida; T Takaki; M Inaba; S Ikehara
Journal:  Clin Exp Immunol       Date:  2007-03       Impact factor: 4.330

7.  Adoptive transfer of syngeneic bone marrow-derived cells in mice with obesity-induced diabetes: selenoorganic antioxidant ebselen restores stem cell competence.

Authors:  Jun Chen; Houwei Li; Francesco Addabbo; Fung Zhang; Edward Pelger; Daniel Patschan; Hyeong-Cheon Park; Mei-Chuan Kuo; Jei Ni; Glenda Gobe; Praveen N Chander; Alberto Nasjletti; Michael S Goligorsky
Journal:  Am J Pathol       Date:  2009-01-15       Impact factor: 4.307

Review 8.  The future of stem cell transplantation in autoimmune disease.

Authors:  Susumu Ikehara
Journal:  Clin Rev Allergy Immunol       Date:  2010-04       Impact factor: 8.667

9.  Impact of whole body irradiation and vascular endothelial growth factor-A on increased beta cell mass after bone marrow transplantation in a mouse model of diabetes induced by streptozotocin.

Authors:  S Nakayama; T Uchida; J B Choi; Y Fujitani; T Ogihara; N Iwashita; K Azuma; H Mochizuki; T Hirose; R Kawamori; M Inoue; H Watada
Journal:  Diabetologia       Date:  2008-10-23       Impact factor: 10.122

10.  Bone marrow stem cell as a potential treatment for diabetes.

Authors:  Ming Li; Susumu Ikehara
Journal:  J Diabetes Res       Date:  2013-04-10       Impact factor: 4.011
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