The clinical course of glycogen disease.

The various types of glycogen disease, of which the author gave the first clinical description in 1928, that can at present be distinguished, are described in terms of the differing clinical and biochemical findings and the enzyme deficiencies more or less characteristic for each type. The clinical course of the author's first two patients with glycogen disease, at present 42 and 38 years old, is given in detail; they have type III of the disease. Some cases of glycogen disease cannot be fitted into the clinical classification of the different types, and for some no definite enzymatic defect to account for the glycogen accumulation has been found. The therapy of glycogen disease is discussed briefly.