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Literature DB >> 140184

Suppression of immune complex-induced inflammation by the chemotactic factor inactivator.

Abstract

Small amounts (10(-10) mol) of purified human chemotactic factor inactivator (CFI) suppress leukocytic infiltration, permeability changes, and hemorrhage associated with acute immune complex-induced injury in rats. The reversed passive dermal Arthus reaction and acute immune complex-induced alveolitis in rats have served as the model systems of inflammation. The mechanism of inhibition does not appear to relate to interference with formation and deposition of immune complexes, or with fixation of complement in vitro or iv vivo. Human CFI inhibits in vitro the chemotactic activity generated in complement-activated rat serum. The inhibitory effects of human CFI are not seen if it is first heat inactivated. The data provide the first direct support for the conclusion that CFI has anti-inflammatory activity.

Entities: Disease Gene Species

Mesh：

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Year: 1977 PMID： 140184 PMCID： PMC372303 DOI： 10.1172/JCI108717

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

16 in total

Review 1. Immunologic tissue injury mediated by neutrophilic leukocytes.

Authors: C G Cochrane
Journal: Adv Immunol Date: 1968 Impact factor: 3.543

2. Biologic role of complement products. Complement-derived leukotactic activity extractable from lesions of immunologic vasculitis.

Authors: P A Ward; J H Hill
Journal: J Immunol Date: 1972-05 Impact factor: 5.422

10. Demonstration of inflammatory mediator-induced inflammation and endothelial cell damage in the anterior segment of the eye.

Authors: F N Rowland; M J Donovan; M Lindsay; W I Weiss; J O'Rourke; D L Kreutzer
Journal: Am J Pathol Date: 1983-01 Impact factor: 4.307

Suppression of immune complex-induced inflammation by the chemotactic factor inactivator.

Review 1. Immunologic tissue injury mediated by neutrophilic leukocytes.

2. Biologic role of complement products. Complement-derived leukotactic activity extractable from lesions of immunologic vasculitis.

3. Characterization of serum inhibitors of neutrophil chemotaxis associated with anergy.

4. Two distinct chemotactic factor inactivators in human serum.

5. Defective regulation of chemotaxis in cirrhosis.

6. Chemotactic factor inactivator in normal human serum.

7. Changes in C3 metabolism during protozoan infection (Babesia rodhaini) in rats.

8. Acute immunologic pulmonary alveolitis.

9. BOUND COMPLEMENT AND IMMUNOLOGIC INJURY OF BLOOD VESSELS.

10. The role of polymorphonuclear leukocytes in the initiation and cessation of the Arthus vasculitis.

1. Immunopathology of the lung: a review.

2. Effect of chlorpromazine on the development of experimental glomerulonephritis and Arthus reaction.

3. Acute inflammatory pulmonary reactions induced by chemotactic factors.

4. Differential effects of pharmacologic agents on the reverse passive Arthus reaction in guinea pigs.

5. Alveolar macrophage-derived chemotactic factor: kinetics of in vitro production and partial characterization.

6. Alterations in activities of anaphylatoxin inactivator and chemotactic factor inactivator during hemodialysis.

7. Neurtrophil degranulation in cadmium-chloride-induced acute lung inflammation.

8. Immune complex injury of the lung.

9. Suppression of acute and chronic inflammation in tumor-bearing rats.

10. Demonstration of inflammatory mediator-induced inflammation and endothelial cell damage in the anterior segment of the eye.