Literature DB >> 140145

An unexpected high frequency of trisomic fetuses in 229 pregnancies monitored for advanced maternal age.

E S Sachs, M G Jahoda, M F Niermeijer, H Galjaard.   

Abstract

In 229 pregnancies monitored because of advance maternal age, 16 (7%) abnormal fetal karyotypes were detected. We found 13 cases of trisomy 21, twice a trisomy 18, and once an additional marker chromosome. The frequency of abnormal fetal karyotypes in different maternal age groups was found to increase from 1:20 at 38--40 years, to 1:16 at 41--43 years, and finally to 1:4.5 in women of 44--46 years. The overall incidence of chromosomal aberrations and specifically of trisomy 21 is considerably higher than that described in retrospective studies.

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Year:  1977        PMID： 140145     DOI： 10.1007/bf00390434

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  6 in total

1.  A survey of mongoloid births in Victoria, Australia, 1942-1957.

Authors:  R D COLLMANN; A STOLLER
Journal:  Am J Public Health Nations Health       Date:  1962-05

2.  Screening programme for prevention of Down's syndrome.

Authors:  Z Stein; M Susser; A V Guterman
Journal:  Lancet       Date:  1973-02-10       Impact factor: 79.321

3.  Down's syndrome in Sweden. An epidemiological study of a three-year material.

Authors:  A Lindsjö
Journal:  Acta Paediatr Scand       Date:  1974-07

4.  Letter: Prospective data on risk of Down syndrome in relation to maternal age.

Authors:  M A Ferguson-Smith
Journal:  Lancet       Date:  1976-07-31       Impact factor: 79.321

5.  Estimates of maternal age-specific risks of Down-syndrome birth in women aged 34-41.

Authors:  E B Hook
Journal:  Lancet       Date:  1976-07-03       Impact factor: 79.321

6.  Prenatal diagnosis of genetic disorders.

Authors:  M F Niermeijer; E S Sachs; M Jahodova; C Tichelaar-Klepper; W J Kleijer; H Galjaard
Journal:  J Med Genet       Date:  1976-06       Impact factor: 6.318
  6 in total
  2 in total

1.  Sixteen years' experience of counselling, diagnosis, and prenatal detection in one genetic centre: progress, results, and problems.

Authors:  P E Polani; E Alberman; B J Alexander; P F Benson; A C Berry; S Blunt; M G Daker; A H Fensom; D M Garrett; V M McGuire; J A Roberts; M J Seller; J D Singer
Journal:  J Med Genet       Date:  1979-06       Impact factor: 6.318

2.  Origin of germ cells and formation of new primary follicles in adult human ovaries.

Authors:  Antonin Bukovsky; Michael R Caudle; Marta Svetlikova; Nirmala B Upadhyaya
Journal:  Reprod Biol Endocrinol       Date:  2004-04-28       Impact factor: 5.211
  2 in total

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