Literature DB >> 1400722

Difference in the concentration of tryptophan metabolites between maternal and umbilical foetal blood.

I Morita1, M Kawamoto, H Yoshida.   

Abstract

Maternal and umbilical foetal blood at delivery were analysed for tryptophan metabolites by using fully automated high-performance liquid chromatography. The metabolites detected in 100 microliters of maternal plasma were kynurenine, serotonin, 5-hydroxyindoleacetic acid, indolelactic acid, indoleacetic acid and indolepropionic acid. These metabolites were present in various amounts in the protein-bound form. Except for indolepropionic acid, the concentrations of tryptophan metabolites were significantly higher in umbilical foetal plasma than in maternal plasma. In addition, 3-hydroxyanthranilic acid was present in umbilical foetal blood, but not in maternal blood. Furthermore, kynurenic acid was also detected in amniotic fluids.

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Year:  1992        PMID： 1400722     DOI： 10.1016/0378-4347(92)80208-8

Source DB:  PubMed          Journal:  J Chromatogr


  13 in total

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Review 4.  The Plasma [Kynurenine]/[Tryptophan] Ratio and Indoleamine 2,3-Dioxygenase: Time for Appraisal.

Authors:  Abdulla A-B Badawy; Gilles Guillemin
Journal:  Int J Tryptophan Res       Date:  2019-08-21

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Authors:  Abdulla A-B Badawy
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Authors:  Abdulla A-B Badawy
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Journal:  Front Endocrinol (Lausanne)       Date:  2020-04-16       Impact factor: 5.555
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