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Literature DB >> 14007115

Light- and electron-microscope studies of the effects of 4-aminopteroylglutamic acid (aminopterin) on the mucous membrane of the small intestine of the rat.

Abstract

Aminopterin, a cytotoxic agent, causes mitotic arrest by interfering with the catabolism of ribonucleoprotein. The effects on the small intestine are demonstrated. The resulting atrophy, with changes in the microvilli, is associated with severely impaired fat absorption.

Entities: Chemical Disease Species

Keywords: AMINOPTERIN/pharmacology; INTESTINE, SMALL/pharmacology

Mesh：

Substances：

Year: 1961 PMID： 14007115 PMCID： PMC1413356 DOI： 10.1136/gut.2.4.346

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

9 in total

1. Electron microscopy studies of butter and corn oil in jejunal mucosa.

Authors: W A THOMAS; R M O'NEAL
Journal: Arch Pathol Date: 1960-02

2. Disorders related to disturbed absorption of the small bowel.

Authors: F H GARDNER; E W STRAUSS
Journal: Adv Intern Med Date: 1960

3. Jejunal biopsy in malabsorptive disorders of the adult.

Authors: R H GIRDWOOD; I W DELAMORE; A W WILLIAMS
Journal: Br Med J Date: 1961-02-04

4. Small intestinal biopsy: diagnostic and research value.

Authors: M SHINER
Journal: Proc R Soc Med Date: 1959-01

5. Jejunal biopsy in adult coeliac disease and allied disorders.

Authors: D J FONE; M J MEYNELL; E L HARRIS; W T COOKE; D B BREWER; E V COX
Journal: Lancet Date: 1960-04-30 Impact factor: 79.321

6. Histopathologic studies in steatorrhea.

Authors: M SHINER; I DONIACH
Journal: Gastroenterology Date: 1960-03 Impact factor: 22.682

7. Jejunal biopsies in sprue.

Authors: C E BUTTERWORTH; E PEREZ-SANTIAGO
Journal: Ann Intern Med Date: 1958-01 Impact factor: 25.391

8. Effects of aminopterin administration on the respiration and morphology of the gastrointestinal mucosa of rats.

Authors: J J VITALE; N ZAMCHECK; J DIGIORGIO; D M HEGSTED
Journal: J Lab Clin Med Date: 1954-04

9. The effects of a folic acid antagonist (aminopterin) on albino rats; a study in the pathogenesis of sprue.

Authors: E WOLL; J J OLESON
Journal: Br J Exp Pathol Date: 1951-10

9 in total

5 in total

Light- and electron-microscope studies of the effects of 4-aminopteroylglutamic acid (aminopterin) on the mucous membrane of the small intestine of the rat.

1. Electron microscopy studies of butter and corn oil in jejunal mucosa.

2. Disorders related to disturbed absorption of the small bowel.

3. Jejunal biopsy in malabsorptive disorders of the adult.

4. Small intestinal biopsy: diagnostic and research value.

5. Jejunal biopsy in adult coeliac disease and allied disorders.

6. Histopathologic studies in steatorrhea.

7. Jejunal biopsies in sprue.

8. Effects of aminopterin administration on the respiration and morphology of the gastrointestinal mucosa of rats.

9. The effects of a folic acid antagonist (aminopterin) on albino rats; a study in the pathogenesis of sprue.

1. DIARRHOEA OF SMALL BOWEL ORIGIN. THE HISTOLOGY OF INTESTINAL BIOPSIES.

2. Electron microscopic changes associated with water absorption in the jejunum.

Review 3. [Cytostatica and small intestine (author's transl)].

Review 4. Experimental intestinal malabsorption states and their relation to clinical syndromes.

5. [Intestinal disaccharidases in rats treated with 5-fluoro-uracil (author's transl)].