Literature DB >> 1399921

Characterization of the plasmid mediated beta-lactamase BIL-1.

D J Payne1, N Woodford, S G Amyes.   

Abstract

A multi-resistant strain of Escherichia coli isolated from a patient from Pakistan was shown to possess a new plasmid-mediated beta-lactamase. This enzyme, designated BIL-1, conferred resistance to extended-spectrum cephalosporins such as cefotaxime and ceftazidime. However, unlike other plasmid-mediated beta-lactamases capable of conferring resistance to these drugs, the BIL-1 was not a member of the TEM or SHV group of plasmid-mediated beta-lactamases and it also conferred resistance to beta-lactam drugs in combination with beta-lactamase inhibitors (i.e. clavulanic acid). The biochemical properties of the enzyme suggest that BIL-1 is related to the Richmond & Sykes Class I chromosomal beta-lactamases. Its inhibition properties by various beta-lactam drugs are similar to the inhibition properties of the chromosomally-encoded P99 enzyme of Enterobacter cloacae.

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Year:  1992        PMID： 1399921     DOI： 10.1093/jac/30.2.119

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  25 in total

Review 1.  Plasmid-determined AmpC-type beta-lactamases.

Authors:  Alain Philippon; Guillaume Arlet; George A Jacoby
Journal:  Antimicrob Agents Chemother       Date:  2002-01       Impact factor: 5.191

2.  First report of Salmonella isolates with the DHA-1 AmpC beta-lactamase in the United Kingdom.

Authors:  E Liebana; M Batchelor; F A Clifton-Hadley; R H Davies; K L Hopkins; E J Threlfall
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

3.  Model system to evaluate the effect of ampD mutations on AmpC-mediated beta-lactam resistance.

Authors:  Amber J Schmidtke; Nancy D Hanson
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

Review 4.  A functional classification scheme for beta-lactamases and its correlation with molecular structure.

Authors:  K Bush; G A Jacoby; A A Medeiros
Journal:  Antimicrob Agents Chemother       Date:  1995-06       Impact factor: 5.191

5.  Nucleotide sequence of a plasmid-mediated cephalosporinase gene (blaLAT-1) found in Klebsiella pneumoniae.

Authors:  L S Tzouvelekis; E Tzelepi; A F Mentis
Journal:  Antimicrob Agents Chemother       Date:  1994-09       Impact factor: 5.191

6.  Gene sequence and biochemical characterization of FOX-1 from Klebsiella pneumoniae, a new AmpC-type plasmid-mediated beta-lactamase with two molecular variants.

Authors:  M Gonzalez Leiza; J C Perez-Diaz; J Ayala; J M Casellas; J Martinez-Beltran; K Bush; F Baquero
Journal:  Antimicrob Agents Chemother       Date:  1994-09       Impact factor: 5.191

Review 7.  Genetics of extended-spectrum beta-lactamases.

Authors:  G A Jacoby
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1994       Impact factor: 3.267

8.  beta-Lactamases responsible for resistance to expanded-spectrum cephalosporins in Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis isolates recovered in South Africa.

Authors:  J D Pitout; K S Thomson; N D Hanson; A F Ehrhardt; E S Moland; C C Sanders
Journal:  Antimicrob Agents Chemother       Date:  1998-06       Impact factor: 5.191

9.  Comparative characterization of the cephamycinase blaCMY-1 gene and its relationship with other beta-lactamase genes.

Authors:  A Bauernfeind; I Stemplinger; R Jungwirth; R Wilhelm; Y Chong
Journal:  Antimicrob Agents Chemother       Date:  1996-08       Impact factor: 5.191

10.  OXA-11, an extended-spectrum variant of OXA-10 (PSE-2) beta-lactamase from Pseudomonas aeruginosa.

Authors:  L M Hall; D M Livermore; D Gur; M Akova; H E Akalin
Journal:  Antimicrob Agents Chemother       Date:  1993-08       Impact factor: 5.191
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