Literature DB >> 1399857

Orally active 2-(alkyloxycarbonyl)-2-alkylideneethyl esters of cephalosporins.

C Hubschwerlen1, R Charnas, P Angehrn, A Furlenmeier, T Graser, M Montavon.   

Abstract

2-(Alkyloxycarbonyl)-2-alkylideneethyl esters of various aminothiazole-oxyimino cephalosporins have been synthesized and studied. They are useful alternatives to the currently existing orally active esters. Among the new esters synthesized, the 3'-azidomethyl cephem ester Ro 41-3399 (7k) presented an oral bioavailability superior to the corresponding pivaloyloxymethyl ester (9) in a rat model and was selected as a candidate for further evaluation.

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Year:  1992        PMID： 1399857     DOI： 10.7164/antibiotics.45.1358

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  3 in total

1.  In vitro activities of Ro 40-6890 against 164 predominantly intestinal members of the families Enterobacteriaceae and Vibrionaceae.

Authors:  P Hohl; J Zollinger-Iten; A von Graevenitz
Journal:  Antimicrob Agents Chemother       Date:  1992-12       Impact factor: 5.191

2.  Antimicrobial activity and disk diffusion susceptibility testing of Ro 40-6890, the active metabolite of the new cephalosporin ester, Ro 41-3399.

Authors:  M A Pfaller; A L Barry; P C Fuchs
Journal:  Antimicrob Agents Chemother       Date:  1993-04       Impact factor: 5.191

3.  Antibacterial properties of Ro 40-6890, a broad-spectrum cephalosporin, and its novel orally absorbable ester, Ro 41-3399.

Authors:  P Angehrn; P Hohl; C Hubschwerlen; M Page; R Then
Journal:  Antimicrob Agents Chemother       Date:  1992-12       Impact factor: 5.191
  3 in total

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