Literature DB >> 1399824

Deficiency of beta 1-6 N-acetylglucosaminyltransferase involved in the biosynthesis of blood group I antigen in the liver of LEC rats.

J Gu1, A Nishikawa, N Matsuura, T Sugiyama, N Taniguchi.   

Abstract

The activities of the beta 1-6 and beta 1-3 N-acetylglucosaminyltransferase, which synthesize blood group I and i antigens, respectively, were measured in various tissues of hepatitis- and hepatoma-predisposed rats (LEC rats). In LEC rats the beta 1-6 N-acetylglucosaminyltransferase activity was barely detectable in the liver, while substantial enzyme activity was found in other tissues. In the control LEA rats the enzyme was expressed in most tissues, including the liver. Immunochemical studies using a monoclonal antibody which recognizes I antigen indicated that the expression of I antigen was less prominent in hepatocytes of LEC rats than in hepatocytes of LEA rats. The level of beta 1-3 N-acetylglucosaminyltransferase activity was constant in most of the tissues during the development. These results indicate that the biosynthesis of I antigen does not occur in the livers of the LEC rats.

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Year:  1992        PMID： 1399824      PMCID： PMC5918958          DOI： 10.1111/j.1349-7006.1992.tb01994.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


Long‐Evans with a cinnamon‐like coat color Long‐Evans with an agouti coat color N‐acetylglucosaminyltransferase 2‐aminopyridine high‐performance liquid chromatography lacto‐N‐neotetraose, Galβ1‐4GlcNAcβ1‐3Galβ14Glc GlcNAcβ1‐3Galβ1‐4Glc 3‐(N‐morpholino)propane‐sulfonic acid
  29 in total

1.  Metabolic predisposition of a novel mutant (LEC rats) to hereditary hepatitis and hepatoma: alterations of the drug metabolizing enzymes.

Authors:  T Sugiyama; N Takeichi; H Kobayashi; M C Yoshida; M Sasaki; N Taniguchi
Journal:  Carcinogenesis       Date:  1988-09       Impact factor: 4.944

2.  Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

Authors:  S M Hsu; L Raine; H Fanger
Journal:  J Histochem Cytochem       Date:  1981-04       Impact factor: 2.479

Review 3.  Blood group ABH and Ii antigens of human erythrocytes: chemistry, polymorphism, and their developmental change.

Authors:  S Hakomori
Journal:  Semin Hematol       Date:  1981-01       Impact factor: 3.851

4.  Reexamination of the pyridylamination used for fluorescence labeling of oligosaccharides and its application to glycoproteins.

Authors:  S Hase; T Ibuki; T Ikenaka
Journal:  J Biochem       Date:  1984-01       Impact factor: 3.387

5.  Biosynthesis in vitro of Ii core glycosphingolipids from neolactotetraosylceramide by beta 1-3- and beta 1-6-N-acetylglucosaminyltransferases from mouse T-lymphoma.

Authors:  M Basu; S Basu
Journal:  J Biol Chem       Date:  1984-10-25       Impact factor: 5.157

6.  New mutation causing hereditary hepatitis in the laboratory rat.

Authors:  M C Yoshida; R Masuda; M Sasaki; N Takeichi; H Kobayashi; K Dempo; M Mori
Journal:  J Hered       Date:  1987 Nov-Dec       Impact factor: 2.645

7.  UDP-GlcNAc:Gal beta 1-4Glc(NAc) beta 1-3N-acetylglucosaminyltransferase. Identification and characterization in human serum.

Authors:  F Piller; J P Cartron
Journal:  J Biol Chem       Date:  1983-10-25       Impact factor: 5.157

8.  Novikoff ascites tumor cells contain N-acetyllactosaminide beta 1 leads to 3 and beta 1 leads to 6 N-acetylglucosaminyltransferase activity.

Authors:  D H van den Eijnden; H Winterwerp; P Smeeman; W E Schiphorst
Journal:  J Biol Chem       Date:  1983-03-25       Impact factor: 5.157

9.  Biosynthesis of blood group I antigens. Identification of a UDP-GlcNAc:GlcNAc beta 1-3Gal(-R) beta 1-6(GlcNAc to Gal) N-acetylglucosaminyltransferase in hog gastric mucosa.

Authors:  F Piller; J P Cartron; A Maranduba; A Veyrières; Y Leroy; B Fournet
Journal:  J Biol Chem       Date:  1984-11-10       Impact factor: 5.157

10.  Elevation of serum alpha-fetoprotein and proliferation of oval cells in the livers of LEC rats.

Authors:  H Takahashi; M Oyamada; Y Fujimoto; M I Satoh; A Hattori; K Dempo; M Mori; T Tanaka; H Watabe; R Masuda
Journal:  Jpn J Cancer Res       Date:  1988-07
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