Literature DB >> 13996274

Effect of guanethidine, hemicholinium and mebutamate on the hypertensive response to eserine and catechol amines.

V VARAGIC, N VOJVODIC.   

Abstract

Guanethidine, hemicholinium and mebutamate were used to study the site and mechanism of the hypertensive response to eserine in the rat. Guanethidine was found to block very effectively the hypertensive effect of eserine and to produce at the same time a very strong potentiation of the response to catechol amines. Hemicholinium, after a certain latent period, also blocked the effect of eserine, at the same time leaving the response to adrenaline and noradrenaline intact. Mebutamate was also found to block the effect of eserine. The results of the present experiments suggest that eserine produces a central adrenergic activation in the rat.

Entities:  

Keywords:  ANTIHYPERTENSIVE AGENTS; BIPHENYL COMPOUNDS; EPINEPHRINE; GUANETHIDINE; NOREPINEPHRINE; PHYSOSTIGMINE; VASOMOTOR SYSTEM

Mesh：

Substances：

Year:  1962        PMID： 13996274      PMCID： PMC1482221          DOI： 10.1111/j.1476-5381.1962.tb01449.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  14 in total

1.  The inhibition of acetylcholine synthesis in brain by a hemicholinium.

Authors:  J E GARDINER
Journal:  Biochem J       Date:  1961-11       Impact factor: 3.857

2.  The action of sympathomimetic amines in animals treated with reserpine.

Authors:  J H BURN; M J RAND
Journal:  J Physiol       Date:  1958-12-04       Impact factor: 5.182

3.  Central respitory depressant action of hemicholinium in the cat.

Authors:  Y KASE; H L BORISON
Journal:  J Pharmacol Exp Ther       Date:  1958-02       Impact factor: 4.030

4.  A new series of cholinesterase inhibitors.

Authors:  J P LONG; F W SCHUELER
Journal:  J Am Pharm Assoc Am Pharm Assoc       Date:  1954-02

5.  The pharmacological properties of 2-methyl-2-sec-butyl-1,3-propanediol dicarbamate (Mebutamate, W-583), a new centrally acting blood pressure lowering agent.

Authors:  F M BERGER; J F DOUGLAS; M KLETZKIN; B J LUDWIG; S MARGOLIN
Journal:  J Pharmacol Exp Ther       Date:  1961-12       Impact factor: 4.030

6.  [2-Octahydro-1-azocinyl)-ethyl]-guanidine sulfate (CIBA 5864-SU), a new synthetic antithypertensive agents].

Authors:  R A MAXWELL; R P MULL; A J PLUMMER
Journal:  Experientia       Date:  1959-07-15

7.  Tissue amine levels and sympathetic blockade after guanethidine and bretylium.

Authors:  R CASS; T L SPRIGGS
Journal:  Br J Pharmacol Chemother       Date:  1961-12

8.  The actions of bretylium: adrenergic neurone blocking and other effects.

Authors:  A L BOURA; A F GREEN
Journal:  Br J Pharmacol Chemother       Date:  1959-12

9.  Norepinephrine depletion as a possible mechanism of action of guanethidine (SU 5864), a new hypotensive agent.

Authors:  R CASS; R KUNTZMAN; B B BRODIE
Journal:  Proc Soc Exp Biol Med       Date:  1960-04

10.  Effect of cocaine and related drugs on the uptake of noradrenaline by heart and spleen.

Authors:  E MUSCHOLL
Journal:  Br J Pharmacol Chemother       Date:  1961-06
View more
  6 in total

1.  Hypothalamic superfusion with muscarinic drugs: their effects on pressor responses to hypothalamic stimulation.

Authors:  A Philippu; N Bohuschke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976       Impact factor: 3.000

2.  [Modification of the eserine pressor effect by propranolol].

Authors:  H Brunner; P Hedwall; L Maître; M Meier
Journal:  Naunyn Schmiedebergs Arch Pharmakol Exp Pathol       Date:  1966

3.  The action of adrenergic neurone blocking agents and other drugs on the pressor responses of various agents in the anaesthetized rat.

Authors:  R D Robson
Journal:  Br J Pharmacol Chemother       Date:  1967-02

4.  Strain differences in the inhibition by hemicholinium-3 of the pressor response to intraventricular injection of neostigmine in rats.

Authors:  H E Brezenoff; J Rusin
Journal:  Br J Pharmacol       Date:  1974-06       Impact factor: 8.739

5.  Oxotremorine-induced hypertension in the anaesthetized rat.

Authors:  J L Walker; D F Weetman
Journal:  Br J Pharmacol       Date:  1970-07       Impact factor: 8.739

6.  THE MECHANISM OF THE PRESSOR RESPONSES TO PHYSOSTIGMINE IN THE RAT AND THEIR MODIFICATION BY MEBUTAMATE AND AMYLOBARBITONE.

Authors:  D DELLABELLA; A GANDINI; M PRETI
Journal:  Br J Pharmacol Chemother       Date:  1964-12
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.