Literature DB >> 13995027

Botulinus toxin: effect on the central nervous system of man.

H R TYLER.   

Abstract

Electrical stimulation of multiple peripheral nerves, elicited "H" reflexes in a patient, 61 years old, with botulism. These reflexes are extremely suggestive of some central release or failure of inhibitory control of a monosynaptic or polysynaptic spinal reflex arc. This "central" action of botulinus toxin is similar to that suggested for tetanus toxin.

Entities:  

Keywords:  BOTULISM; CENTRAL NERVOUS SYSTEM; TOXINS AND ANTITOXINS

Mesh:

Substances:

Year:  1963        PMID: 13995027     DOI: 10.1126/science.139.3557.847

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  6 in total

1.  Infectious Diseases: Annual Review of Significant Publications.

Authors:  H A Reimann
Journal:  Postgrad Med J       Date:  1963-08       Impact factor: 2.401

2.  Effects of type A botulinum toxin on the cholinergic transmission at spinal Renshaw cells and on the inhibitory action at Ia inhibitory interneurones.

Authors:  R Hagenah; R Benecke; H Wiegand
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-10       Impact factor: 3.000

Review 3.  Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology.

Authors:  Marco Pirazzini; Ornella Rossetto; Roberto Eleopra; Cesare Montecucco
Journal:  Pharmacol Rev       Date:  2017-04       Impact factor: 25.468

Review 4.  Botulinum toxin type A in motor nervous system: unexplained observations and new challenges.

Authors:  I Matak; Z Lacković; M Relja
Journal:  J Neural Transm (Vienna)       Date:  2016-09-01       Impact factor: 3.575

5.  Vascular thrombi and neuronal alterations in human botulism.

Authors:  H R Tyler
Journal:  Acta Neuropathol       Date:  1968-01-02       Impact factor: 17.088

6.  Botulism: clinical neurophysical findings.

Authors:  R Hagenah; A Müller-Jensen
Journal:  J Neurol       Date:  1978-02-14       Impact factor: 4.849

  6 in total

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