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Literature DB >> 139888

Molecular conformation of sodium heparan sulphate in the condensed phase.

Abstract

By using the X-ray-diffraction results reported previously for sodium heparan sulphate, a twofold helical conformation with an axially projected disaccharide repeat (h) equal to 0.93 nm has been examined in detail. On the basis of a repeating sequence of 1,4-alpha-D-glucosamine and 1,4-beta-D-glucuronic acid, trial and stereochemically feasible molecular models were computer-generated. An optimum twofold helical conformation is proposed, incorporating stabilizing intra-chain hydrogen bonds across both glycosidic linkages.

Entities: Chemical

Mesh：

Substances：

Year: 1977 PMID： 139888 PMCID： PMC1164533 DOI： 10.1042/bj1610495

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

14 in total

1. Hyaluronic acid: structure of a fully extended 3-fold helical sodium salt and comparison with the less extended 4-fold helical forms.

Authors: W T Winter; P J Smith; S Arnott
Journal: J Mol Biol Date: 1975-12-05 Impact factor: 5.469

1. alpha-L-iduronate ring conformations in heparin and heparin derivatives. 13-C Nuclear-magnetic-resonance analysis and titration data for variously desulphated and periodate-oxidized heparins.

Authors: L A Fransson; T N Huckerby; I A Nieduszynski
Journal: Biochem J Date: 1978-10-01 Impact factor: 3.857

1 in total

Molecular conformation of sodium heparan sulphate in the condensed phase.

1. Hyaluronic acid: structure of a fully extended 3-fold helical sodium salt and comparison with the less extended 4-fold helical forms.

2. The disaccharide repeating-units of heparan sulfate.

3. High molecular-weight heparan sulfate from the cell surface.

4. Production of heparin related mucopolysaccharides by mammalian cells in culture.

5. Heparan sulfates of cultured cells. II. Acid-soluble and -precipitable species of different cell lines.

6. Heparan sulfates of cultured cells. I. Membrane-associated and cell-sap species in Chinese hamster cells.

7. The effect of calcium on the macromolecular properties of heparan sulfate.

8. Evidence for the existence of a multichain proteoglycan of heparan sulphate.

9. Distribution of sulphate and iduronic acid residues in heparin and heparan sulphate.

10. X-ray-diffraction patterns from chondroitin 4-sulphate, dermatan sulphate and heparan sulphate.

1. alpha-L-iduronate ring conformations in heparin and heparin derivatives. 13-C Nuclear-magnetic-resonance analysis and titration data for variously desulphated and periodate-oxidized heparins.