Literature DB >> 13985782

Teratogenic effect of 5-hydroxytryptamine in mice.

E POULSON, J M ROBSON, F M SULLIVAN.   

Abstract

The subcutaneous injection of a single dose of 5-hydroxytryptamine into pregnant mice produced a large number of fetal abnormalities, mostly of the eyes, limbs, and tail; the skull and central nervous system were also sometimes affected. These effects could result from the action of the drug on placental function and blood supply.

Entities:  

Keywords:  ABNORMALITIES; FETAL DEATH; SEROTONIN

Mesh：

Substances：

Year:  1963        PMID： 13985782     DOI： 10.1126/science.141.3582.717

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  6 in total

Review 1.  Maternal SSRIs experience and risk of ASD in offspring: a review.

Authors:  Zainab Fatima; Aqeela Zahra; Maria Ghouse; Xu Wang; Zonghui Yuan
Journal:  Toxicol Res (Camb)       Date:  2018-07-11       Impact factor: 3.524

2.  Effects of drugs on placental function and their relation to congenital abnormalities.

Authors:  J Davies; J M Robson; F M Sullivan
Journal:  Proc R Soc Med       Date:  1969-04

3.  LSD: its effect upon 5-hydroxytryptamine in embryonic development of Xenopus laevis.

Authors:  P C Baker
Journal:  Experientia       Date:  1971-05-15

4.  The fine structure and dihydroxyphenylalanine uptake of the developing parietal cells of the rat stomach.

Authors:  A Penttilä
Journal:  Z Anat Entwicklungsgesch       Date:  1970

5.  Embryotoxic and teratogenic action of 5-hydroxytryptamine: mechanism of action in the rat.

Authors:  P B Marley; J M Robson; F M Sullivan
Journal:  Br J Pharmacol Chemother       Date:  1967-11

6.  5-Hydroxytryptamine, placental function and toxaemia of pregnancy.

Authors:  J M Robson; F M Sullivan
Journal:  Proc R Soc Med       Date:  1966-08
  6 in total

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