Hereditary globulin factors and immune tolerance in man.

Eight nontransfused donors of antibodies against a hereditary gamma-globulin factor lacked the factor, but each donor's mother had it. The probability that this is a chance observation is .00003. A ninth donor had been transfused, and she and her mother both lacked the factor. It is assumed that each nontransfused donor's antibody was formed against his mother's gamma-globulin and that immune tolerance had not been induced.