Literature DB >> 13978666

Breakdown of rat-liver ergosomes in vivo after actinomycin inhibition of messenger RNA synthesis.

T STAEHELIN, F O WETTSTEIN, H NOLL.   

Abstract

Ribosomes isolated from rat liver occur predominantly in the form of aggregates (ergosomes) corresponding to multiples of 73S particles held together by messenger RNA. After injecting rats with actinomycin, these aggregates gradually break down in vivo to 73S monomers and 113S dimers. We conclude that the observed breakdown results from the degradation of messenger RNA and the prevention by actinomycin of the synthesis of new messenger RNA.

Entities:  

Keywords:  ACTINOMYCIN; LIVER; RNA

Mesh：

Substances：

Year:  1963        PMID： 13978666     DOI： 10.1126/science.140.3563.180

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  22 in total

1.  THE STABILITY OF LIVER MESSENGER RNA.

Authors:  M REVEL; H H HIATT
Journal:  Proc Natl Acad Sci U S A       Date:  1964-05       Impact factor: 11.205

2.  POLYRIBOSOME-BOUND NUCLEOSIDE TRIPHOSPHATASES IN ESCHERICHIA COLI.

Authors:  I D RAACKE; J FIALA
Journal:  Proc Natl Acad Sci U S A       Date:  1964-02       Impact factor: 11.205

3.  The effect of phenobarbitone on protein synthesis by liver polyribosomes in fed and starved rats.

Authors:  G Ragnotti; M G Aletti
Journal:  Biochem J       Date:  1975-01       Impact factor: 3.857

4.  Minimum estimate of the lifetime of histone messenger RNA of HeLa cells.

Authors:  P Liberti; A Festucci; C Baglioni
Journal:  Mol Biol Rep       Date:  1973-06       Impact factor: 2.316

5.  Kinetics of antibody production by single cells. II. The action of transcription and translation inhibitors upon the metabolism of haemolysin-secreting cells.

Authors:  J Weyer; A E Bussard
Journal:  Immunology       Date:  1972-06       Impact factor: 7.397

6.  Characterization of the rapidly labeled hybridizable RNA synthesized in L5178Y mouse leukemic cells. Hybridization lifetime studies.

Authors:  M Meltz; S Okada
Journal:  Biophys J       Date:  1971-07       Impact factor: 4.033

7.  The effect of whole-body x-irradiation of guinea pigs on liver ribonucleic acid synthesis.

Authors:  E J Hidvégi; E Bölöni; J Holland; F Antoni; V Várterész
Journal:  Biochem J       Date:  1970-02       Impact factor: 3.857

8.  Inhibition of translation in liver polyribosomes by a new substituted thiopseudourea with antitumour action.

Authors:  N F González-Cadavid; F Herrera Quijada
Journal:  Biochem J       Date:  1974-02       Impact factor: 3.857

9.  Synthesis of murine leukemia virus proteins associated with virions assembled in actinomycin D-treated cells: evidence for persistence of viral messenger RNA.

Authors:  J G Levin; M J Rosenak
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

10.  Factors controlling amino acid incorporation by ribosomes from krebs II mouse ascites-tumour cells.

Authors:  I M Kerr; N Cohen; T S Work
Journal:  Biochem J       Date:  1966-03       Impact factor: 3.857
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